肿瘤相关性成纤维细胞与肿瘤关系的初探  

Preliminary study of the relationship between tumor associated fibroblast and tumorigenesis

作　　者：王鑫[1] 王洁[2] 丁九立[3] 王彤[4] 张春玉[5] 

机构地区：[1]黑龙江省医院耳鼻咽喉科,哈尔滨150036 [2]黑龙江省医院眼科,哈尔滨150036 [3]黑龙江省医院放免中心,哈尔滨150036 [4]黑龙江省医院检验科,哈尔滨150036 [5]哈尔滨医科大学医学遗传学研究室,150081

出　　处：《国际遗传学杂志》2012年第3期178-182,共5页International Journal of Genetics

基　　金：黑龙江省卫生厅科研项目（2011-676）

摘　　要：肿瘤相关性成纤维细胞（tumorassociatedfibroblast，TAF）是肿瘤间质中的重要成员之一，随着肿瘤微环境的深入研究，其与肿’瘤的相互关系已日益受到重视。TAF可以通过分泌多种细胞因子参与肿瘤的发生、发展、侵袭、转移及血管生成等过程，针对TAF的肿瘤靶向治疗也已悄然兴起。该文就TAF与肿瘤发生发展的关系加以综述。Tumor-associated fibroblast （tumor associated fibroblast, TAF ） is an important mem- ber of the tumor interstitium. With in-depth study of the tumor microenvironment, the relationship between TAF and tumorigenesis has received increasing attention. TAF has been involved in tumor genesis, development, invasion, metastasis and angiogenesis through the secretion of various cytokines. Tumor tar- geted therapy for the TAF has also been gradually rising. This review reports the progress in the study on relationship between TAF and tumor development and progression.

关 键 词：肿瘤相关性成纤维细胞 肿瘤微环境 肿瘤发生发展 

分 类 号：R730.2[医药卫生—肿瘤]