肝素点眼预防后囊混浊的实验与临床研究  

An expeimental and clinical study on heparin eyedrops to prevent posterier capsular opacification

作　　者：李家臣[1] 祝磊[1] 王翔[1] 孙凌宏[2] 

机构地区：[1]河南省眼科研究所,河南郑州450003 [2]焦作市第二人民医院,河南焦作454151

出　　处：《河南医学研究》2000年第1期61-63,共3页Henan Medical Research

基　　金：河南省医学科学院科研基金

摘　　要：目的 :探讨肝素点眼对白内障囊外摘除术后后囊混浊的作用。方法 :在 2 4只兔建立白内障动物模型 ,随机分为肝素点眼组和对照组 ,行双眼白内障囊外摘除术。 10 0例 ( 10 0眼 )老年性白内障 ,随机分为肝素点眼组和对照组 ,行超声乳化摘除联合人工晶体植入 ,术后应用裂隙灯显微镜及检眼镜观察角膜、前房及后囊混浊情况 ,并对兔后囊膜行组织学检查。结果 :肝素点眼组与对照组前房反应及后囊混浊眼数有显著性差异 (P <0 .0 5 )。结论 :肝素可减少早期前房反应 ,抑制后囊混浊的形成 ,为一种简便。Objective: To investigate the effect of heparin eyedrops to prevent posterior opacification after extracapsular cataract extraction (ECCE).Methods: 24 rabbits models of cataract were established and were randomly assigned to heparin eyedrops group and control group for ECCE.100 patients with senile cataract were randomly assighed to heparin eyedrops group and control group for phacoemulfication,postoperative the change of cornea,anterior chamber and posterior capsule were observed.Results: There was asignificant difference in anterior chamber reaction and posterior capsular opacification (PCO)between heparin group and control group( P <0.05),but there was no significant difference in cornea.Conclusion: Heparin reduces anterior chamber reaction in early stage and has a significant inhibitory effect on PCO formation.It is a handy,safe and availabe way for preventing PCO

关 键 词：肝素 白内素 超声乳化术 后囊混浊 

分 类 号：R776.1[医药卫生—眼科]