小儿重症肌无力血清乙酰胆碱受体抗体的测定及其临床意义  

Determination of Serum Acetylcholine Receptor Antibody in Children with Myasthenia Gravis and its Clinical significance

作　　者：吴秀丽[1] 张洪[1] 林艾羽[1] 慕容慎行[1] 

机构地区：[1]福建医科大学附属第一医院神经内科,350005

出　　处：《医学理论与实践》2000年第3期137-138,共2页The Journal of Medical Theory and Practice

摘　　要：为研究小儿重症肌无力(MG)血清乙酰胆碱受体抗体(AchRab)的含量改变及其临床意义。采用固相酶联免疫吸附法检测血清AchRab的含量。结果MG患儿血清AchRab阳性率为81%,明显高于健康对照组和非MG病人组(P<0.01)。MG患儿治疗后血清AchRab的含量明显低于治疗前,其阳性率分别为55%和81%(P<0.05)。结果提示AchRab的测定可作为MG患儿早期诊断和疗效观察的指标。Using enzyme - linked immunosorbent assay (ELISA), We measured the level of the serum acetylcholine receptor antibody (AchRab)in children with myasthema gravis(MG). The results showed the level of AchRab in children with MG was significantly higher than that in control's and non -MG group(P <0. 01). the positive rate was 81% and 0% respectively. Compared with pre - treatment patients, the level of serum AchRab in post - treatment patients was significantly decreased( P<0. 05) ,and the positive rates decreased as 55%. These results suggested that detecting of serum AchRab may assist in early diagnosis of MG and be regarded as an index to judge the efficacy of treatment.

关 键 词：重症肌无力 乙酰胆碱受体 抗体 儿童 测定 

分 类 号：R746.1[医药卫生—神经病学与精神病学]