三氟乙酸乙酯的合成  

Synthesis of Ethyl trifluoroacetate

作　　者：张建立[1] 李公春[1] 王志敏[1] 杨风岭[1] 

机构地区：[1]许昌学院化学化工学院,河南许昌461000

出　　处：《河北化工》2012年第6期24-25,47,共3页Hebei Chemical Industry

基　　金：河南省教育厅自然科学基金项目(2007150036);河南省自然科学基金项目(082300420110)

摘　　要：以三氟乙酸、无水乙醇为原料,采用0.2mol三氟乙酸、0.2g对甲苯磺酸,酸醇摩尔比为1∶1.5,加热回流反应2h,然后边反应边分馏,得到粗产物,粗产物分别经无水氯化钙和无水硫酸镁干燥,蒸馏后得到三氟乙酸乙酯,收率达75.9%。Using trifluoroacetic acid,anhydrous ethanol as raw materials, the p-toluenesulfonic acid as catalyst, ethyl trifluoroacetate was synthesized via the esterification reaction and the yield was 75. 9%. The conditions were as follows： 0.2 mol trifluoroacetic acid, 0.2 g p-toluenesulfonic acid, acid-alcohol molar ratio of 1 ： 1.5 under the condi- tions of refluxing 2 hours, then fraet while reacting. Collection of crude products were dried by anhydrous calcium chloride and anhydrous magnesium sulfate,respectively. Ethyl trifluoroacetate was prepared after distillation.

关 键 词：三氟乙酸乙酯 三氟乙酸 对甲苯磺酸 酯化反应 

分 类 号：O623.624[理学—有机化学]