右旋酮洛芬缓释胶囊的制备及体外释药研究  

Studies on Preparation and Release in vitro of Dexketoprofen Sustained-release Capsule

作　　者：沈万翠[1] 栾立标[1] 

机构地区：[1]中国药科大学药学院,药剂教研室,南京210009

出　　处：《抗感染药学》2012年第2期104-107,共4页Anti-infection Pharmacy

摘　　要：目的:研究右旋酮洛芬缓释胶囊制备的处方条件。方法:采用喷雾干燥法制备右旋酮洛芬缓释细粒,填充入胶囊制成缓释胶囊,测定缓释胶囊(或细粒)的体外释放度,并考察制备处方条件对药物释放度的影响。结果:喷雾干燥法制备右旋酮洛芬缓释细粒,填充入胶囊即为缓释胶囊;在最优处方条件下缓释胶囊1h内体外累计释药量不超过30%,24h不低于90%。结论:该处方条件的右旋酮洛芬缓释胶囊的生产工艺简单可行,最终所得的缓释胶囊具有较好的缓释特征。Objective： To develop a dexketoprofen sustained-release capsule and to study its release in vitro. Methods： The dexketoprofen sustained-release fine granule was firstly developed by spray drying method and then by filling into empty capsule to obtain the dexketoprofen sustained-release capsules.The in vitro drug release test was carried out. Meanwhile, the effects of formulation factors on the accumulative release rate were investigated. Results： The dexketo- profen sustained-release capsule was developed by filling the dexketoprofen sustained release fine granules which were successfully prepared by spray drying method. Under the optimal conditions,the drug release was no more than 30% for 1 h, and no less than 90% for 24 h. Conclusion：The process for preparing sustained-release capsules is simple and reliable. The obtained sustained-release capsules have a good sustained-release behavior in vitro.

关 键 词：右旋酮洛芬 喷雾干燥 缓释胶囊 体外释放 

分 类 号：R944.9[医药卫生—药剂学]