富硒酵母兔体内药物动力学研究  

STUDIES ON PHARMACOKINETICS OF SELENIUM ENRICHBD YEAST IN RABBITS

作　　者：黄祥贤 倪兆良 陆茂松[2] 茅勤 王辛强[2] 

机构地区：[1]启东市药品检验所,江苏226200 [2]启东肝癌防治研究所,江苏226200

出　　处：《中国医药工业杂志》1990年第6期266-268,共3页Chinese Journal of Pharmaceuticals

摘　　要：用金膜电极微分阳极溶出伏安法测定了富硒酵母在兔体内的药物动力学参数:半衰期(t_(1/2))4.15h,吸收速率常数(h_a)0.444h^(-1),消除速率常数(k)0.167h^(-1),药物达峰时间(T_(max))3.744h,药时曲线下面积(AUC_(0→∝))623.75ng/ml·h。实验结果表明,富硒酵母较亚硒酸钠具有生物利用度大、维持时间长、峰浓度高的特点,是一优于亚硒酸钠的补硒剂。Pharmacokinetic parameters of selenium enriched yeast in rab- bits after oral administration were determined by differential anodic stripping voltammetry using gold membrane electrode: t_(1/2)4.15h, K_a 0.444h^(-1), k 0.167h^(-1), T_(max)3.744h, AUC_(0→∞) 623.74ng/ml·h. The results indicated that selenium enriched yeast had better bioavailability, longer effect and higher peak concentration than sodium selenite.

关 键 词：富硒酵母 药代动力学 生物利用度 

分 类 号：R969.1[医药卫生—药理学]