颅脑肿瘤手术行急性等容血液稀释的临床研究  

Study of acute normovolemic hemodilution in brain neoplasm patients

作　　者：黄中华 叶凤青 甘丽霞 谭立清 张庆敏 莫井延 张学刚 

机构地区：[1]广西区人民医院,530021

出　　处：《广西医学》2000年第1期9-10,共2页Guangxi Medical Journal

基　　金：广西区科委自然科学基金!No - 97310 37

摘　　要：目的 :研究急性等容血液稀释对颅脑肿瘤病人血流动力学、氧转运及凝血纤溶方面的影响 ,探讨该方法的安全性。方法 :选择颅脑肿瘤手术病人 12例 ,麻醉后从右颈内静脉放置 Swan～ Ganz导管 ,从桡动脉放血 8ml/ kg,同时等速从静脉输入等量的海脉素。分别测定血液稀释前后的血流动力学 ,氧转运及凝血纤溶方面的指标。结果 :CO、 SV、 DO2 显著增加(P <0 .0 5 ) ;PT延长 (P <0 .0 5 ) ;PL T较血液稀释前减少 ,其余指标无明显改变。结论 :急性等容血液稀释对颅脑肿瘤病人的血流动力学及凝血纤溶功能影响小 ,而氧供增加 ,是一安全有效的血液保护方法。Objective:To study the effect of acute normovolemic hemodilution on hemodynamics,oxygen transport and blood coagulation and plasmin in brain neoplasm patients Methods:Twelve patients with brain neoplasm undergoing acute normovolemic hemodilution were randomly selected The general anesthesia was maintained The Swan Ganz was shoved through right jugular The blood was drawn through left radial artery The average amounts of blood withdrawal were 8ml·kg -1 of total weights per person And in the meanwhile the same volume of haemaccel was infused introvenously Hemodynamics,oxygen transport and blood coagulation and plasmin of patients were measured before and after hemodilution Results:CO,SV and DO 2 had a little increasement(P<0 05),while KPTT,PT prolonged(P<0 05) and PLT decreased a little after hemodilution Conclusion:Acute normovolemic hemodilution had less effects on hemodynamics and blood coagulation and plasmin in brain neoplasm patients,while oxygen transport increased It is a safe and effective treatment

关 键 词：颅脑肿瘤 外科手术 血液稀释 临床研究 

分 类 号：R739.410.5[医药卫生—肿瘤]