手术切除ⅢA期-N2非小细胞肺癌预后影响因素分析  

Influencing factors on the prognosis of the surgical resection of stage ⅢA-N2 non-small cell lung cancer

作　　者：罗强[1] 蓝碧洋[1] 钟醒能[1] 黄绍华[1] 张晓安[1] 黄斯阳[1] 

机构地区：[1]广西壮族自治区民族医院外二科,广西南宁530001

出　　处：《海南医学》2012年第12期9-11,共3页Hainan Medical Journal

摘　　要：目的分析手术切除IIIA期-N2非小细胞肺癌患者预后的影响因素。方法回顾性分析1996年3月至2007年1月在我院行手术治疗的124例IIIA期-N2非小细胞肺癌患者的临床资料,分析各种可能影响其生存率的因素,使用Kaplan-Meier方法分析生存率,应用Log-rank方法对各单因素与预后的关系进行检验,使用Cox模型对多因素进行分析。结果患者在术后的1年、3年、5年的生存率分别是65.7%、48.2%、17.3%,单因素分析中,肿瘤的切除情况、N2淋巴结发生转移的个数、淋巴结发生转移的组数、术后的化疗情况都对生存率有影响。多因素分析显示,N2淋巴结发生转移的个数、术后的化疗情况是预后的主要影响因素。结论ⅢA期-N2非小细胞肺癌的患者术后生存率比较低,对预后生存率影响最大的是N2淋巴结发生转移的个数以及化疗情况。Objective To analyze the influencing factors on the prognosis of the surgical resection of stage ⅢA-N2 non-small cell lung cancer （NSCLC）. Methods The clinical data of 142 patients of ⅢA-N2 NSCLC re- ceived surgical resection from March 1996 to January 2007 in our hospital were retrospectively analyzed. The factors that might affect the survival rate was analyzed using the Kaplan-Meier method. The relationship between each single factor and the prognosis was tested with Log-rank, using the Cox model analysis multivariate. Results The 1-year, 3-year, 5-year survival rates were 65.7%, 48.2%, 17.3%, respectively. According to univariate analysis, tumor resec- tion, the transferred number of N2 lymph node, the transferred number of lymph node group, postoperative chemother- apy were found to exert an impact on the survival rate. Conclusion The survival rate of patients with ⅢA stage-N2 NSCLC was low. The factors influencing the prognosis mostly were the transferred number of N2 lymph node, and the cycles of chemotherapy.

关 键 词：非小细胞肺癌 手术切除 预后 影响因素 

分 类 号：R734.2[医药卫生—肿瘤]