帕罗西汀合并奥氮平治疗60例抑郁症伴焦虑障碍的对照研究  

Paroxetine combined with Olanzapine in the treatment of depression with anxiety disorder

作　　者：梁家騋[1] 杨红梅[1] 王成美[2] 宁静[1] 王学燕[1] 

机构地区：[1]济南市精神卫生中心,山东济南250032 [2]山东省千佛山医院

出　　处：《中国民康医学》2012年第11期1283-1285,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:探讨帕罗西汀合并奥氮平治疗抑郁症伴焦虑障碍的疗效。方法:将60例抑郁症伴焦虑的患者,随机分成合并组(帕罗西汀合并奥氮平治疗)和单用组(单用帕罗西汀治疗)各30例,共治疗8周,采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、副反应量表(TESS)评定疗效和不良反应。结果:治疗后两组HAMD和HAMA评分较治疗前均有显著性下降(P<0.01)。治疗后第1、2、4、8周末,合并组的HAMD和HAMA评分均显著低于单用组,且差异具有统计学意义(P<0.05)。合并组显效率显著高于单用组,差异具有统计学意义(P<0.05)。两组不良反应少而轻,发生率无显著差异(P>0.05)。结论:帕罗西汀合并奥氮平治疗抑郁症伴焦虑障碍,具有起效快,疗效好,不良反应少的优点。Objective：To Paroxetine combined with Olanzapine in the treatment of depression with anxiety disorder.Methods：60 cases of depression with anxiety patients were randomly divided into randomly divided into consolidation group（Paroxetine Combined with Olanzapine treatment） and single group（single with Paroxetine treatment） of each of the 30 cases,a total of 8 weeks of treatment,using the Hamilton Depression Rating scaling（HAMD）,Hamilton Anxiety Scale（HAMA）,deputy reaction scales（TESS） to evaluate the curative effect and side reaction.Results： In two groups after the treatment,HAMD and HAMA score before treatment was significantly（P0.05）.Conclusions： The Paroxetine combined with Olanzapine in the treatment of depression with anxiety disorders has fast effect,good curative effect,less adverse reaction advantages.

关 键 词：奥氮平 帕罗西汀 抑郁症 焦虑障碍 

分 类 号：R749.41[医药卫生—神经病学与精神病学]