阿立哌唑与利培酮治疗80例首发精神分裂症临床研究  

First-episode Schizophrenia Patients Treated with Aripiprazole or Risperidone: a Randomized Controlled Trial

作　　者：朱琼[1] 王任昌 罗爱华[1] 邓睿[1] 刘锡英[1] 

机构地区：[1]四川省达州市民康医院,四川达州635006

出　　处：《中国民康医学》2012年第11期1323-1324,1329,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:评价阿立哌唑治疗首发精神分裂症的疗效及安全性。方法:将80例首发精神分裂症患者随机分为阿立哌唑组40例和利培酮组40例。采用阳性与阴性症状量表、副反应量表于治疗前及治疗第2、4、8周末评定临床疗效与药物不良反应。结果:两组间阳性与阴性症状量表同期比较无显著性差异(P>0.05)。组内治疗前后比较均有极显著性差异(P<0.01)。阿立哌唑有效率92.5%,利培酮有效率90.0%;阿立哌唑不良反应较利培酮轻,未见明显的体重增加及内分泌改变。结论:阿立哌唑与利培酮疗效相当,不良反应少且轻,值得临床推广应用。Objective：To evaluate the efficacy and security of aripiprazole that used it to treat first-episode schizophrenia patients.Methods：80 patients who satisfied the standard of first-episode schizophrenia were distributed two groups random.Both of the group aripiprazole and risperidone had 40 patients.The efficacy was evaluated by Scale for Assessment of Positive Symptoms（SAPS） and Scale for Assessment of Negative Symptoms（SANS） at baseline,2-week,4-week and 8-week.The security was evaluated by Treatment Emergent Symptom Scale（TESS） at 2-week,4-week and 8-week.Results： Two groups had not statistical significant（P〉0.05） in SAPS and SANS at the same periods,but had obviously statistical significant（P〈0.01） compared with baseline.The efficient was 92.5% of the group that treated with aripiprazole and 90.0% of the group that treated with risperidone.The aripiprazole group had less emergent symptoms compared with risperidone,such as weight gain and endocrine changes.Conclusions： Aripiprazole has the same efficacy with risperidone in treat first-episode schizophrenia patients,but has less emergent symptoms.

关 键 词：精神分裂症 阿立哌唑 利培酮 

分 类 号：R749.3[医药卫生—神经病学与精神病学]