复合红花油制剂降血脂作用初探  

Study on the Action of Blood Fat Reduction of Co-safflower Oil Preparation

作　　者：杨晓君[1,2] 郭雪婷[2] 王颖[2] 徐芳[2] 

机构地区：[1]新疆医科大学,乌鲁木齐830011 [2]新疆农业大学食品科学与药学学院,乌鲁木齐830052

出　　处：《新疆农业科学》2012年第5期868-872,共5页Xinjiang Agricultural Sciences

基　　金：新疆维吾尔自治区自然科学基金项目(200521106)

摘　　要：【目的】研究配伍红花籽油、红花黄素及其复合制剂是否具有降脂作用。【方法】小鼠造模用药后使用全自动生化仪,测定动物血清中总胆固醇(CHO-C)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)含量并统计进行T检验或者方差分析。【结果】配伍红花籽油、红花黄素及其复合制剂对血清中CHO-C、TG、LDL-C的增高均有抑制作用,对HDL-C数值的降低有提升作用。【结论】红花黄素可降低实验性高脂血症小鼠甘油三酯、总胆固醇、低密度脂蛋白,具有降低血脂的作用,红花黄素和配伍红花籽油复合制剂低剂量组方后,作用强于红花色素单一组分药物。[ Objective ] The project aimed to study whether the safflower oil, safflower yellow and compatibility preparation have the action of reducing blood lipid. [ Method ] The experiment extracted and then filtered and concentrated safflower yellow flute by using the microwave method. The safflower yellow was separated with macroporous resin column chromatography. After making the high lipid modes of mice, the cholesterol total （CHO -C）, triglyceride （TG）, high density lipoprotein （HDL- C）, low density lipoprotein （ LDL - C） were determined by using auto - biochemistry apparatus and their relevant variance was tested and analyzed , too. [ Result] Safflower oil, safflower yellow and compatibility preparation have inhibitory action to the increasing of CHO, TG, LDL in blood serum, and upgrade action to the decreasing of HDL - C. [ Conclusion] Saff^ower yellow can decrease CHO, TG, LDL of the experimental hyperlipemia mice, so they have the action of reducing blood fat. The effective of low - dose group of the compatibility （ safflower yellow and safflower oil） is stronger than the single drug of safflower yellow.

关 键 词：降血脂 配伍红花籽油 红花黄素 

分 类 号：S567[农业科学—中草药栽培] S509.9[农业科学—作物学]