奥曲肽治疗急性粘连性肠梗阻疗效观察  

Efficacy of Octreotide for the Treatment of Acute Adhesive Intestinal Obstruction

作　　者：邱晋[1] 任小宝[1] 陈翔宇[1] 李科[1] 陈小雄[1] 

机构地区：[1]重庆市第三军医大学西南医院急救部,重庆400038

出　　处：《现代生物医学进展》2012年第12期2319-2321,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨生长抑素对腹部手术后急性粘连性肠梗阻的治疗作用。方法:70例急性粘连性肠梗阻患者随机分为观察组与对照组各35例。对照组予胃肠减压、灌肠、补液及抗感染治疗等常规治疗;观察组在此基础上加用奥曲肽(生长抑素类似物)0.1 mg皮下注射,每8h一次,治疗72 h。观察两组患者腹痛评分、腹痛缓解时间、胃肠减压量、肛门恢复排气时间、立卧位腹部平片、临床缓解情况。结果:观察组34例(97.1%)临床缓解,明显高于对照组的28例(80.0%)(P<0.05)。与对照组相比,观察组在治疗第1、2天后腹痛评分明显下降(均为P<0.01),腹痛缓解时间显著缩短(P<0.01),治疗第1、2、3天的胃肠减压量均显著减少(均为P<0.01),恢复排气时间也明显缩短(P<0.01)。结论:急性粘连性肠梗阻在常规治疗基础上加用生长抑素,可明显改善临床症状,提高疗效。Objective： To investigate the efficacy of octreotide for the treatment of acute adhesive intestinal obstruction.Methods： 70 patients with acute adhesive intestinal obstruction were randomly divided into observation group and control group with each of 35 cases. Control group were treated with decompression, enemas, rehydration and anti-infection drugs and such as conventional treatment. On this basis, observation group was added with octreotide （somatostatin analogue）0, lmg subcutaneously, once every 8h, treatment for 72 h. Abdominal pain score, pain relief time, the amount of decompression, anal exhaust time to restore, establish supine abdominal plain film and clinical remission were observed. Results： 34 patients （97.1%） of the observation group got clinical remission, which was significantly higher than 28 cases （80.0%） of the control group （P〈0.05）. Compared with the control group, the abdominal pain score of the observation group was significantly decreased at 1 and 2 days after treatment （P〈0.01）, and pain relief time was significantly shorter （P〈0.01）, gastrointestinal decompression volume decreased significantly at 2 and 3 days after treatment （P〈0.01）, recovery time was significantly shorter （P〈0.01）. Conclusion： Based on the conventional treatment, somatostatin can significantly improve the clinical symptoms and efficacy for the treatment of acute adhesive intestinal obstruction.

关 键 词：粘连性肠梗阻 奥曲肽 生长抑素 

分 类 号：R574.2[医药卫生—消化系统]