依达拉奉治疗急性脑梗死的临床观察  

Effect of edaravone on acute cerebral infarction patients

作　　者：陈颖青[1] 

机构地区：[1]三亚市中医院神经内科,海南三亚572000

出　　处：《中国热带医学》2012年第4期476-477,508,共3页China Tropical Medicine

摘　　要：目的评价依达拉奉注射液治疗急性脑梗死的疗效。方法采用随机对照试验,选择住院发病48h内的急性脑梗死患者60例,随机分为依达拉奉治疗组(30例)及对照组(30例),对照组治疗方法采用川芎嗪+阿司匹林肠溶片,治疗组在对照组基础上,加用依达拉奉注射液30mg静滴,每日2次,30min内滴完,疗程均为14d,分别在治疗前和治疗7d及14d后,对其神经功能进行评估。结果治疗7d后,治疗组有效率为76.7%,对照组为50.0%,两组间有显著差异(P<0.05);14d后治疗组有效率为96.7%,对照组为66.7%,两组间有显著差异(P<0.05)。结论依达拉奉能有效改善急性脑梗死的神经功能缺失,并能更好地控制脑梗死的进展,无明显不良反应。Objective To assess the clinical efficacy of edaravone in treatment of acute cerebral infarction.Methods Sixty patients with acute cerebral infarction admitted within 48 hours of onset were enrolled in this study and randomly allocated to edaravone group and control group each consited of 30 cases.Those in control group received ligustrazine injection plus aspirin Enteric-coated Tablets.Besides the similar therapy as used for the control group,the edaravone group received i.v.edaravone 30mg,twice a day for 14 days.The patients＇ the neural function in both groups were analyzed before treatment,7 days and 14 days after treatment.Results A week after the effective rates in edarabvone group,control were 76.7% and 50% showing significant diffferences（P0.05）,while that two weeks after treatment were 96.7% and 66.7% in the treatment group and the control group,also showed significnt differences（P0.05）.Conclusion Edaravone can effectively improve the neurological function of acute cerebral infarction,and inhibits the progress of cerebral infarction without adverse reactions.

关 键 词：依达拉奉 急性脑梗死 自由基清除剂 

分 类 号：R743.3[医药卫生—神经病学与精神病学]