^(18)氟-脱氧葡萄糖和^(11)碳-乙酸PET/CT显像在原发性肝癌及肝脏肿瘤样病变诊断中的初步研究  

The diagnosis of ^(18)F-fluorodexoxyglucose and ^(11)C-acetate PET/CT scanning in primary liver tumors and tumor-like diseases:a preliminary study

作　　者：胡裕效[1] 朱虹[1] 卢光明[2] 杨桂芬[1] 栗全营[1] 

机构地区：[1]南京军区南京总医院核医学科,江苏南京210002 [2]南京军区南京总医院医学影像科,江苏南京210002

出　　处：《医学影像学杂志》2012年第3期400-404,共5页Journal of Medical Imaging

基　　金：国家自然科学基金重大国际(地区)合作研究项目(项目批准号:81120108013;依托项目编号:30670600);江苏省自然科学基金(编号:BK2011665)

摘　　要：目的探讨18氟-脱氧葡萄糖(18 F-fluorodexyoxyglucose,18F-FDG)和11碳-乙酸(11 C-acetate,11 C-ACT)PET/CT显像在原发性肝癌及肝脏肿瘤样病变诊断中的作用。方法回顾性分析9例患者资料,其中男性7例,女性2例,平均年龄70.2岁,所有患者均为肝内单发病灶。治疗前均先行18 F-FDG PET/CT,后行11 C-ACT PET/CT检查,两次检查间隔时间不超过1周。其中有7例肝细胞肝癌(hepatocelluar carcinoma,HCC)、1例胆管细胞癌(cholangiocarcinoma,CCC)、1例肝内感染性病灶,均经病理学或临床随访证实。结果 7例HCC患者18 F-FDG PET/CT显像均为阴性,11 C-ACT PET/CT显像有6例为阳性。18F-FDG PET/CT和11 C-ACT PET/CT显像均未发现1例高分化胆管细胞癌。对于1例肝内炎性病灶,18F-FDG PET/CT显像为阳性,而11 C-ACT PET/CT显像为阴性。结论①11 C-ACT PET/CT显像可以用来探测那些呈18 F-FDG等或低摄取的HCC病灶;②对于高分化的CCC,18 F-FDG PET/CT显像有可能会表现为假阴性结果;③11 C-ACT PET/CT显像可以用来诊断肝内感染性病灶。Objective This preliminary study was designed to investigate the performance of positron emission tomography/ computer tomography（PET/CT） scanning for primary liver tumors and tumor-like diseases using 18F-fluorodexyoxyglucose（18F-FDG） and 11C-acetate（11C-ACT）.Methods Nine patients（M：F=7：2,with mean age of 70.2）,each of whom had one lesion only,were selected for this retrospective study.All patients had undergone a ＂dual-tracer＂ PET/CT scanning with 11C-ACT followed by 18F-FDG before treatment.The interval of two imaging was no more than one week.Verified by histopathology or clinical follow-up,there were 7 hepatocelluar carcinomas（HCCs）,1 cholangiocarcinoma（CCC） and 1 infecting-lesion.Both PET/CT images were interpreted by two experienced nuclear physicians,based on visual assessment or semiquantitative analysis.Results 18F-FDG PET/CT showed equal or low uptake in 7 HCCs,and 11C-ACT PET/CT showed high uptake in 6 of them.Either 18F-FDG or 11C-ACT PET/CT scanning did not detect the well-differentiated CCC.The infecting-lesion showed high uptake in 18F-FDG PET/CT imaging,but equal in 11C-ACT PET/CT imaging.Conclusion ①11C-ACT PET/CT scanning would be used to detect HCCs,which showed equal or low uptake in 18F-FDG;②18F-FDG PET/CT scanning,might show a false-negative in detecting the well-differentiated CCC;③11C-ACT PET/CT scanning might be used to diagnose the infecting-lesions in liver.

关 键 词：原发性肝癌 18氟-脱氧葡萄糖 11碳-乙酸 正电子发射体层摄影 

分 类 号：R735.7[医药卫生—肿瘤] R817[医药卫生—临床医学]