2型糖尿病及单纯性糖耐量受损对急性脑梗死患者病情及预后的影响  

The impact of type Ⅱ diabetes mellitus and isolated impaired glucose tolerance on severity and prognosis of patients with acute cerebral infarction

作　　者：谢连红[1] 李擎[1] 

机构地区：[1]上海市徐汇区中心医院神经内科,200031

出　　处：《江苏医药》2012年第10期1207-1209,共3页Jiangsu Medical Journal

摘　　要：目的探讨2型糖尿病(T2DM)及单纯性糖耐量受损(I-IGT)对急性脑梗死患者病情及预后的影响。方法根据血糖情况,将195例急性脑梗死患者分为血糖正常组(54例)、T2DM组(63例)和I-IGT组(78例)。采用美国国立卫生院卒中评分量表(NIHSS)评估患者入院时及入院1周时的病情。采用改良Rankin评分量表(mRS)于发病后1个月、3个月评估患者的预后。结果三组患者入院时NIHSS评分相仿(P>0.05);入院1周时,T2DM组和I-IGT组NIHSS评分均显著高于正常组(P<0.05)。T2DM组发病后1个月、3个月的预后不良率分别为57.1%、44.4%,I-IGT组分别为48.7%、41.0%,均明显高于与正常组的31.5%、20.4%(P<0.05)。T2DM组与I-IGT组并发症发生率分别为77.8%和70.5%,亦明显高于与正常组的27.8%(P<0.05)。结论 T2DM及I-IGT使急性脑梗死患者病情加重,预后不良。Objective To explore the influence of type Ⅱ diabetes mellitus （T2DM） and isolated impaired glucose tolerance（I-IGT） on the severity and prognosis in the patients with acute cerebral infarction（ACI）. Methods According to blood glucose（BG） level, 195 cases with ACI were divided into three groups of A（ 54 cases with euglycemia）, B （ 63 cases with T2DM） and C （ 78 cases with I-IIGT）. The pathogenetic condition was assessed by NIHSS on admission and 1 week after admission. The prognosis of 1 month and 3 month after admission was evaluated by mRS. Results There were no significant differences in NIHSS scores among three groups on admission（P〈0. 05）, which in 1 week after admission were significantly higher in groups of B and C than those in group： A （P〈0. 05）. In 1 month and 3 months after admission, the incidence rates of poor prognosis were 57. 1% and 44. 4% in group B and 48. 7% and 41.0% in group C,which were higher than 31.5% and 20. 4% in group A（P〈0. 05）. The ineidence rate of complication was 77.8% in group B and 70. 5% in group C,which was higher than 27. 8% in group A（P〈0. 05）. Conclusion T2DM and I-IGT can enhance the severity of cerebral infraction and exacerbate the prognosis in the patients with ACI.

关 键 词：急性脑梗死 2型糖尿病 单纯性糖耐量受损 

分 类 号：R743[医药卫生—神经病学与精神病学]