淋巴瘤脾脏浸润的^(18)F-FDG PET/CT表现  

^(18)F-FDG PET/CT manifestations of spleen infiltration of lymphoma

作　　者：吴江[1] 朱虹[1] 王新刚[1] 桂一[1] 胡裕效[1] 杨桂芬[1] 

机构地区：[1]南京军区南京总医院核医学科,江苏南京210002

出　　处：《中国医学影像技术》2012年第6期1157-1160,共4页Chinese Journal of Medical Imaging Technology

基　　金：江苏省自然科学基金(BK2011665);南京军区南京总医院立项课题(2011024)

摘　　要：目的探讨18F-FDG PET/CT在诊断淋巴瘤脾脏浸润中的应用价值。方法回顾经18 F-FDG PET/CT诊断为淋巴瘤脾脏浸润的42例患者,分析脾脏体积、病灶大小、病灶密度、病灶最大标准摄取值(SUVmax)和正常肝脏SUVmax。结果 42例淋巴瘤脾脏浸润的18F-FDG PET/CT表现分为3型,其中Ⅰ型(单纯弥漫型浸润)24例、Ⅱ型(单纯结节型浸润)13例,Ⅲ型(混合型浸润)5例。在淋巴瘤浸润脾脏病灶的SUVmax中,Ⅱ型、Ⅲ型>Ⅰ型(P均<0.05),Ⅱ型与Ⅲ型差异无统计学意义。霍奇金病(HD)与非霍奇金淋巴瘤(NHL)、B细胞淋巴瘤与T细胞/NK细胞淋巴瘤、B细胞淋巴瘤与HD的脾脏浸润PET/CT分型差异均无统计学意义(P=0.07、0.18、0.17);T细胞/NK细胞淋巴瘤与HD的脾脏浸润PET/CT分型差异有统计学意义(P=0.02)。结论 18F-FDG PET/CT诊断脾脏淋巴瘤浸润有明显优势,其表现以Ⅰ型和Ⅱ型为主;淋巴瘤浸润脾脏结节样病灶的18F-FDG摄取显著高于弥漫性病灶;T细胞/NK细胞淋巴瘤累及脾脏较HD更多表现为Ⅰ型。Objective To observe the value of 18F-FDG PET/CT in patients with spleen infiltration of lymphoma.Methods Forty-two patients diagnosed as spleen infiltration of lymphoma with 18F-FDG PET/CT were retrospectively analyzed.The spleen volume,size,density,maximal standardized uptake value（SUVmax） of the lesions in the spleen and the liver were analyzed.Results Three types of spleen infiltration were displayed with 18F-FDG PET/CT,including 24 patients of type Ⅰ（pure diffuse infiltration）,13 of type Ⅱ（pure nodular infiltration） and 5 of type Ⅲ（mixed infiltration）.SUVmax of splenic lesions in type Ⅱ and type Ⅲ were higher than that of type Ⅰ（both P0.05）,but there was no statistical difference between type Ⅱ and type Ⅲ.There was no statistical difference about PET/CT performances of spleen infiltration respectively between Hodgkin diseases（HD） and non-Hodgkin lymphoma（NHL）,B-cell lymphoma and T-cell/NK-cell lymphoma,nor between B-cell lymphoma and HD（P=0.07,0.18,0.17）,while significant difference was found between T-cell/NK-cell lymphoma and HD（P=0.02）.Conclusion 18F-FDG PET/CT has advantages in diagnosing spleen infiltration of lymphoma,which mainly display as type Ⅰ and type Ⅱ.18F-FDG uptake of nodular-like lesions was significantly higher than that of diffuse lesions in spleens when involved by lymphoma.Compared with HD,T-cell/NK-cell lymphoma involving spleen mostly showed as type Ⅰ.

关 键 词：淋巴瘤 脾脏 肿瘤转移 体层摄影术 发射型计算机 体层摄影术 X线计算机 18F氟脱氧葡萄糖 

分 类 号：R733[医药卫生—肿瘤] R817.4[医药卫生—临床医学]