Cyfra21-1和CEA及CRP联合检测对食管癌诊断价值的探讨  

Clinical value of combined detection of Cyfra21-1,CEA and CRP for esophageal cancer

作　　者：张琳[1] 吴兴平[1] 丁伟龙[2] 杨娟[3] 刘万里[1] 

机构地区：[1]中山大学肿瘤防治中心检验科华南肿瘤学国家重点实验室,广东广州510060 [2]广东医学院检验系,广东东莞523808 [3]广州医学院附属广州市第一人民医院检验科,广东广州510180

出　　处：《中华肿瘤防治杂志》2012年第9期667-670,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨外周血肿瘤相关细胞角蛋白19片段抗原21-1(Cyfra21-1)、癌胚抗原(CEA)及C反应蛋白(CRP)联合检测对食管癌的诊断价值。方法:电化学发光免疫分析法测定278例食管癌患者与100名健康体检者外周血清的Cyfra21-1、CEA和CRP的水平,t和χ2检验进行数据统计分析。结果:食管癌组血清Cyfra21-1、CEA和CRP的水平及阳性率分别为(6.4±4.8)ng/mL与41.7%、(6.1±2.2)ng/mL与30.2%及(57.8±63.6)mg/L与53.2%,均显著高于健康对照组的(4.5±1.5)ng/mL与14.0%、(5.8±0.9)ng/mL与8.0%及(10.2±1.9)mg/L与22.0%,P<0.05。随着临床分期的递增,血清Cyfra21-1、CEA和CRP的水平和阳性率也不同程度上升。食管癌患者血清Cyfra21-1、CEA和CRP联合检测的敏感性和特异性明显高于单项检测,P<0.05。结论:联合检测食管癌血清中Cyfra21-1、CEA和CRP水平变化,对食管癌早期诊断和鉴别具有重要的临床价值。OBJECTIVE： To investigate the clinic significance of serum levels of Cyfra21-1,CEA and CRP in Esophageal cancer. METHODS： The serum Cyfra21-1, CEA and CRP were detected by electrochemiluminescence with 278 esophageal cancer case and 100 healthy controls. Statistical analysis was performed with t test and χ^2 test. RESULTS：The serum levels of Cyfra21-1, CEA and CRP in esophageal cancer group were （6.4 ± 4.8）, （6.1±2.2）, （57.8 ± 63.6） mg/L, respectively,and in healthy controls were （4.5±1.5）, （5.8±0.9）, （10.2± 1.9） mg/L,respectively. The serum levels of Cyfra21-1 ,CEA and CRP of esophageal cancer group were significantly higher than those in healthy controls（P〈0.05）. The positive rates of Cyfra21-1, CEA and CRP in esophageal cancer patients were 41.7 %, 30.2 % and 53.2 %, respectively,and in healthy controls were 14.0% ,8.0% and 22.0%. The positive rate and levels of Cyfra21-1 ,CEA and CRP were increasing according to the clinical stage. The sensitivity and specificity of combination of Cyfra21-1 ,CEA and CRP of the esophageal cancer were obviously higher than that in healthy controls（P〈0. 05）. CONCLUSION： Combined detection of the serum Cyfra21-1 ,CEA and CRP levels had an important clinical value for the early diagnosis and identity for detecting the esophageal cancer.

关 键 词：食管肿瘤 角蛋白 癌胚抗原 C反应蛋白质 

分 类 号：R735.1[医药卫生—肿瘤]