盐酸帕诺洛司琼联合地塞米松预防顺铂化疗引起恶心和呕吐的临床观察  

Palonosetron plus dexamethasone for the prevention of chemotherapy-induced nausea and vomiting in patients receiving multiple cycles of multiple-day cisplatin-based chemotherapy

作　　者：高红飞[1] 梁颖[1] 周宁宁[1] 张东生[1] 刘克军[1] 刘婷智[1] 吴海鹰[1] 

机构地区：[1]中山大学肿瘤防治中心内科华南肿瘤学国家重点实验室,广东广州510060

出　　处：《中华肿瘤防治杂志》2012年第9期707-709,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：为了评价帕诺洛司琼联合地塞米松预防顺铂化疗所致恶心和呕吐的疗效和安全性,在81例患者接受顺铂化疗中使用帕诺洛司琼和地塞米松预防恶心和呕吐,观察急性和延迟性无呕吐率、恶心程度、安全性以及多程化疗中的无呕吐率。81例患者共接受了247个周期的帕诺洛司琼和地塞米松的止呕治疗。在第1个周期中,无恶心率为28.4%(23/81),急性和延迟性无呕吐率分别为46.9%(38/81)和76.5%(62/81),主要不良反应为便秘(25.9%)、呃逆(23.4%)、乏力(13.6%)和头晕(11.1%)。第1～6个周期的无呕吐率分别为45.7%(37/81),36.1%(22/61),32.6%(15/46),27.3%(9/33),23.1%(3/13)和23.1%(3/13)。初步研究结果提示,帕诺洛司琼联合地塞米松安全有效地预防顺铂化疗中的恶心和呕吐,但疗效在多程化疗中不能很好地维持。The objective of this study was to assess the antiemetic efficacy and tolerability of palonosetron plus dexamethasone in patients receiving multiple cycles of multiple-day cisplatin-based chemotherapy. Eighty-one chemotherapynaive adult patients undergoing multiple-day cisplatin-based chemotherapy for solid cancer,received palonosetron and dex- amethasone. Nausea-free rate during overall periods,no emesis rate during multiple cycles chemotherapy and safety were evaluated. Eighty-one patients received a total of 247 cycles of 3-day cisplatin-based chemotherapy. In cycle 1, Nausea-free rate in the overall （daysl--8） periods was 28.4%（23/81）. No emesis rate was 46.9% （38/81） in the acute （daysl--3） phase,76.5 % （62/81） in the delayed （days 4--8） phase, respectively. This antiemetic regimen was safe and well-tolerated. The most commonly treatment-related side effects were constipation（25.9 % ）, hiccups（23.4 % ）, fatigue（13.6 % ） and headache（11. 1%）. The rate of no ernesis during cycle 1 to 6 was 45. 7%（37/81）,36. 1%（22/61）,32. 6% （15/46）, 27.3%（9/33）,23.1%（3/13） and 23.1 % （3/13）,respectively. This study shows that palonosetron in combination with dexamethasone is safe and it can effectively prevents chemotherapy-induced nausea and vomiting in patients treated with multiple-day cisplatin-based chemotherapy but the efficacy can not maintain during multiple cycles.

关 键 词：药物疗法 联合 化学预防 恶心 呕吐 

分 类 号：R730.5[医药卫生—肿瘤]