乳腺癌组织VEGF和p120表达及其临床意义的探讨  

Expressions of VEGF and p120 in breast cancer tissues and their clinical significance discussion

作　　者：董梁[1] 刘奇伦[2] 

机构地区：[1]宁夏医科大学2009级研究生六班,宁夏银川750004 [2]宁夏医科大学总院肿瘤医院,宁夏银川750004

出　　处：《中华肿瘤防治杂志》2012年第10期757-760,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:观察血管内皮生长因子(VEGF)及连环蛋白p120在乳腺腺病和乳腺癌中的表达,探讨两者与乳腺癌临床病理特征的临床意义。方法:采用免疫组化SP法检测62例乳腺癌及26例乳腺腺病组织中VEGF和p120的表达情况。结果:乳腺癌组织中VEGF和p120的异常表达率分别为77.4%(48/62)和80.6%(50/62),与良性组相比差异有统计学意义,P=0.000。两者均与肿瘤病理分级和TNM分期相关,但均与肿瘤大小无相关。VEGF在有腋窝淋巴结转移的癌组织中阳性率明显高于无淋巴结转移者,P=0.017;p120表达情况和淋巴结转移无关,P=0.072。两者在乳腺癌组织中的表达具有正相关性,P=0.011。结论:VEGF及p120在乳腺癌组织中异常表达,并与乳腺癌浸润转移关系密切,是乳腺癌发生发展的生物学指标之一,联合检测对评估预后及临床治疗有指导意义。OBJECTIVE： To investigate the expressions of VEGF and p120 in breast cancer and mammary adenosis, and explore the different TNM staging,pathologic tYpes,lymph node metastasis of breast cancer patients of the clinical significance. METHODS： The expression of VEGF and p120 in 62 cases of breast cancer and 26 cases of mammary adeno sis were assessed by immunohistochemistry SP method. RESULTS： The abnormal expression rate of VEGF and p120 were 77.4% （48/62）and 80.60%（50/62） in patients with breast cancer. There were significant differences between the abnormal expression rate in breast cancer and benign breast disease （P=0. 000）. The expression of them had completely positively correlated with histological grade and clinical stage. But had no correlation with tumor size. The expression of VEGF had completely positively correlated with axillary lymph node status（P= 0. 017）. The expression of p120 had no correlation with axillary lymph node status（P= 0. 072）. The expression of VEGF and p120 are positively related in breast cancer （P=0. 011）. CONCLUSIONS： VEGF and p120 are important factors in the development and invasion of breast cancer metastasis. Combined detection of VEGF and p120 will be used to evaluate breast cancer prognosis and guide treatment.

关 键 词：乳腺肿瘤 血管内皮生长因子 连环蛋白P120 血管内皮钙黏蛋白 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]