阿德福韦酯联合复方丹参滴丸治疗慢性乙型肝炎肝纤维化  

Clinical Sutdy of Adefovir Dipivoxil Combined with Compound Dan-shen Dripping Pill in the Treatment of Hepatic Fibrosis of Chronic Hepatitis B Patients

作　　者：龚海龙[1] 刘永芬[2] 陈爱民[2] 

机构地区：[1]江西省乐安县人民医院,乐安344300 [2]江西中医学院,南昌330004

出　　处：《实用中西医结合临床》2012年第3期6-7,共2页Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨阿德福韦酯联合复方丹参滴丸治疗慢性乙型肝炎肝纤维化的临床疗效。方法:慢性乙型病毒性肝炎肝纤维化患者共70例,分为治疗组和对照组。对照组35例仅使用阿德福韦酯治疗。治疗组35例在对照组的基础上加用复方丹参滴丸口服。两组疗程均为48周。结果:治疗后两组患者血清HBV-DNA、肝纤维化指标较治疗前均明显下降(P<0.01),治疗组肝纤维化指标明显低于对照组(P<0.05)。结论:阿德福韦酯联合复方丹参滴丸既能有效抑制乙肝病毒复制,同时可以明显改善慢性乙型肝炎肝纤维化指标。Obje0tive：To explore the effect of adetbvir cllplvoxll combmecl with compouna uan-snen arlpplng pill（ CDDP） In the treatmant of hepatic fibrosis of chronic hepatitis B patients.Methods：70 Patients with chronic hepatitis and liver fibrosis were randomly divided into treatment group and control group.35 Patients in the control group were treated only by adefovir dipivoxil.Other 35 patients of treatment group were treated by CDDP based on the control group. Treatment times of two groups were all 48 weeks.Results： After therapy,the level ofHBV-DNA, HA,LN,PCIIIand CIV intwo groups decreased obviously （P〈0.01）,and there was obviously difference in two groups （P 〈0.05）.Conclusion：Adefovir dipivoxil combined with CDDP have obvious activity against HBV and meliorated chronic hepatitis B with hepatic fibrosis.

关 键 词：阿德福韦酯 复方丹参滴丸 肝纤维化 乙型肝炎 

分 类 号：R575.1[医药卫生—消化系统]