原发性支气管肺癌MRI信号强度与DNA含量的关系  

Investigation on the Relationship of MRI Signal Intensity and DNA Content of Lung Cancer

作　　者：许冬明[1] 陈九如[1] 杨振燕 詹松华 汤如勇 李日乐 

机构地区：[1]上海市闸北区中心医院放射科,上海200070 [2]上海市甘泉医院放射科,上海200065 [3]上海市甘泉医院病理科,上海200065

出　　处：《中国医学影像学杂志》2000年第2期131-133,108,共4页Chinese Journal of Medical Imaging

摘　　要：目的：探讨肺癌ＭＲＩ信号强度与ＤＮＡ倍体的关系。材料与方法：２６例肺癌患者，术前用Ｒｅｓｏｎｅｘ０．３８Ｔ磁共振成像系统，行横断面 ＳＥ Ｔ_１加权，ＧＲ序列成像，增强后行 ＳＥ Ｔ_１加权成像。术后标本用 ＩＣＭ－１００细胞图像分析仪，测定该例肺癌的ＤＮＡ含量及ＳＰＦ值。结果：Ｔ_１加权平扫二倍体肿瘤信号强度比（病变／椎体）显著小于异倍体肿瘤的信号强度比。二倍体肿瘤的ＳＰ值也显著小于异倍体肿瘤的ＳＰＦ值。但肿癌ＭＲＩ信号强度比不能反映其ＳＰＦ值。结论：ＭＲＩ信号强度在一定程度上可反映肿瘤细胞的倍体情况，即可间接地反映肿瘤细胞的生物学行为。Purpose:To explore the relationship of MRI signal intensity and DNA content of lung cancer. Materials and Methods: Twen ty-six cases of lung cancer proved by surgery and pathology were examined with a 0.38T MR system before operation. The pulse sequences includ SE T_1WI, gradient echo and gadolinium(Gd-DTPA)-enhanced SE T_1WI sequences. DNA content was measured by a imaging analyz er(ICM-100)and the SPF percentage (S Phase Fraction)was calculated. Results: Signal-intensity ratios of lesion to vertebra on unenhanced SE T_1WI and SPF percentage were significantly smaller in diploid lesions than in aneuploid lesions. But MRI signal intensity ratify can not reflect SPF status. Conclusion: MRI signal-intensity ratios can reflect DNA ploidy in a certain degree, therefore, indirectly reflecting the ma lignant biological behavior of lung cancer.

关 键 词：肺癌 MRI 信号强度 DNA含量 S期分数 

分 类 号：R734.2[医药卫生—肿瘤]