吸烟对大鼠肺循环血流动力学及肺血管反应性的影响  

EFFECTS OF CIGARETTE SMOKING ON PULMONARY HEMODYNAMICS AND PULMONARY VASOREACTIVITY TO ACUTE HYPOXIA IN RATS

作　　者：胡清华[1] 赵海波[1] 张然[1] 何丽萍 冯长建[1] 王迪浔[1] 

机构地区：[1]同济医科大学病理生理学教研室

出　　处：《中国应用生理学杂志》1990年第1期62-65,共4页Chinese Journal of Applied Physiology

摘　　要：本实验用大鼠29只,进行人工通气吸入烟气,初步探讨了吸烟对肺循环的影响。其中7只观察了吸烟对肺循环血流动力学的直接影响,结果表明,吸烟可致右心室收缩压、心输出量下降及心率减慢,肺循环阻力无明显改变。观察22只大鼠吸烟后缺氧所致肺循环血流动力学变化,结果表明,吸烟可使缺氧性肺血管反应降低,而且发生在肺循环血流动力学变化之前。Effects of cigarette smoking for 30 min on pulmonary hemodynamics were studied in 7anesthetized Sprague-Dawley rats. Right ventricular systolic pressure (RVSP), cardiac output (CO), stroke volume (SV), and heart rate (HR) decreased significantly during smoking for 10-15 min, while pulmonary, vascular resistance (PVR) remained unchanged during cigarette smoking. The effect of smoking on pulmonary vasoreactivity to hypoxia was studied in 22 anesthetized Sprague-Dawley rats. The result showed that cigarette smoking for 5 min caused a significant depression of pulmonary vasoreactivity to hypoxia.

关 键 词：吸烟 肺循环 血流动力学 血管反应 

分 类 号：R363.13[医药卫生—病理学]