立体定向手术治疗海洛因依赖的远期随访分析  

A long term follow up analysis of stereotactic surgery for heroin dependence

作　　者：周连银 唐运林 汪鲁刚 张奕生 刘刚 徐越 潘香 蔡美玲 

机构地区：[1]解放军458医院神经外科,广州510602

出　　处：《中国微侵袭神经外科杂志》2012年第6期258-259,共2页Chinese Journal of Minimally Invasive Neurosurgery

基　　金：国家十一五科技支撑计划项目(编号:2007BAI0703)

摘　　要：目的评估立体定向毁损术治疗海洛因依赖的手术疗效，分析术后复吸原因。方法回顾性分析接受脑立体定向术的154例海洛因成瘾者的临床资料，采用症状自评量表对病人精神卫生状况进行调查随访。结果随访154例，时间5-6年，其中复吸52例（33．8％，复吸组），未复吸102例（66．2％，未复吸组）。复吸组术后躯体化、强迫症状、敌对、偏执、精神病性等因子明显高于未复吸组和国内常模（均P〈0．05）。结论立体定向手术是海洛因依赖的安全有效的治疗方法。强迫症状和人格障碍的改善是消除心理依赖的基础及手术戒毒治疗成功的重要因素；精神病性和躯体化是复吸的主要原因。Objective To evaluate the surgical outcome of stereotactic lesioning for heroin dependence and analyze the reasons for relapse. Methods Clinical data of 154 heroin addicts treated by stereotactic surgery were analyzed retrospectively. The state of mental health was measured by self-rating symptom scale in follow-up study. Results All the patients were followed up for 5 to 6 years. Relapse occurred in 52 patients （33.8%） as relapse group and no relapse in 102 （66.2%） as non-relapse group after surgery. The scores in somatization, obsessive-compulsive symptom, hostility, paranoid, psychotism were higher in relapse group than those in non-relapse group and domestic norm （all P 〈 0.05）. Conclusions Stereotactic surgery is a safe and effective method for heroin dependence. The improvements in obsessive-compulsive symptom and the personality disorder are the bases of eliminating the psychological dependence and also important factors of successful withdrawal from abused drugs by surgery. Somatization and psychotism are the key reasons for relapse.

关 键 词：海洛因依赖 立体定位技术:随访研究 

分 类 号：R749.61[医药卫生—神经病学与精神病学]