播散性肿瘤治疗策略的共进化分析  

Co-evolutionary Analysis on Strategy for Therapy of Spreading Cancer

作　　者：吴克复 郑国光 马小彤 竺晓凡 郭晔 宋玉华 

机构地区：[1]中国医学科学院、北京协和医学院,血液学研究所、血液病医院实验血液学国家重点实验室,天津300020

出　　处：《中国实验血液学杂志》2012年第3期523-526,共4页Journal of Experimental Hematology

基　　金：国家自然科学基金(编号30971111,81170511,81070426,81090412);天津市自然科学基金(编号11JCZDJC18200,11JCZDJC18000);教育部新世纪优秀人才支持计划(NCET-08-0329)

摘　　要：现代文献中将以生态学和进化论的观点和方法考察医学问题的领域称为进化医学(evolutionary medicine),已经为代谢病的发生提供了合理的解释;近年来用体细胞"宏进化"(macroevolution)的观点阐明肿瘤的发生、发展,为肿瘤研究提供了新的思路。本文综合近年来非经典免疫学(non-classical immunology)理论和肿瘤进化的"基因组理论"(genome theory),对国内、外流行的"与癌共舞"的肿瘤治疗策略,从共进化博弈的视角进行了初步分析,强调通过改变生活方式增强机体耐受力在提高机体适合度中的重要性,是"与癌共舞"策略的基础;认为肿瘤播散不等同于肿瘤细胞恶性变,而应该与其它慢性病一样耐心治疗;呼吁加强相关的基础与临床研究,提高"与癌共舞"的效益。Evolutionary medicine can give rational explanation for metabolism diseases via ecology and evolutionary theory.Recently,the view of somatic cell macroevolution was used in the study on the genesis and development of tumors,which provided new insight in the research work on tumors.In this article,the well-adopted tumor therapy strategy,＂Dancing with Cancer＂,was analyzed preliminarily from the point of co-evolution game theory,based on the non-classical immunology theory and genome theory.The importance of increasing host fitness by changing host life-style to enhance tolerance was emphasized,which is the basis of the Dancing with Cancer strategy.On the other hand,the spreading tumor cells are not equally malignant and spreading tumors should be treated as other chronic diseases.Finally,basic and clinical research should be strengthened to improve the efficiency of the＂Dancing with Cancer＂strategy.

关 键 词：肿瘤治疗 帯瘤生存 进化医学 进化博弈论 

分 类 号：R730.5[医药卫生—肿瘤]