CYP2E1RsaI/PstI位点多态性与口腔癌易感性的Meta分析  

A meta-analysis of CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk

作　　者：牛玉明[1] 沈铭[2] 陈盛[2] 陈睿[1] 倪小兵[1] 陈永吉[1] 胡媛媛[1] 

机构地区：[1]湖北医药学院附属十堰市太和医院口腔医学中心,湖北十堰442000 [2]南京医科大学附属江苏省口腔医院口腔颌面外科,江苏南京210029

出　　处：《临床口腔医学杂志》2012年第6期339-341,共3页Journal of Clinical Stomatology

基　　金：湖北医药学院附属太和医院博士启动基金(2011QD05);湖北医药学院2011年度优秀中青年科技创新团队项目(2011CZX01)

摘　　要：目的:运用Meta的分析方法研究CYP2E1 Rsa I/Pst I多态性与口腔癌易感性的相互关系。方法:检索VIP,CNKI和PubMed数据库中有关CYP2E1 Rsa I/Pst I多态性与口腔癌易感性关联研究的文献,以OR值和95%的可信区间为效应指标,应用Rev Man 4.2软件进行Meta分析,并使用STATA 11.0软件对发表偏倚进行检验。结果:纳入12个病例对照研究,共计1259例口腔癌患者和2262例正常对照,Meta分析结果显示,总人群中c1/c2 vs.c1/c1(OR=1.30,95%CI=1.04～1.62),c1/c2+c2/c2 vs.c1/c1(OR=1.32,95%CI=1.07～1.64)。结论:CYP2E1突变基因型c2可能会增加口腔癌发生的风险。Objective：To assess the relationship between CYPP4502E1 Rsa I/Pst I genetic polymorphism and oral cancer. Method： The relevant literatures were search in VIP, CNKI and Pubmed. The data of genotype distributions and other information were extracted in the groups of patients and healthy control and calculated with the RevMan 4.2 software for heterogeneity test and Odd rations. Result： 12 published case-control studies with 1259 patients with oral cancer and 2262 controls were selected. Overall, the pooled ORs indicated a significant association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk（for c1 / c2 vs. c1 / c1 （OR=1.30,95 % CI=1.04-1.62） ,c1/ c2＋c2 / c2 vs. cl / cl （OR=1.32,95 % CI=1.07-1.64）. Conclusion：This meta-analysis demonstrates that CYP2E1 Rsa I/Pst I c2 allele may be an increase risk factor for oral cancer.

关 键 词：口腔癌 细胞色素P4502E1 多态性 META分析 

分 类 号：R739.8[医药卫生—肿瘤]