细胞凋亡相关蛋白Bcl-2对OLP病损区淋巴细胞聚集的影响  

nfluence on accumulation of lymphocyte in oral lichen planus by Bcl-2

作　　者：满一[1] 阿达来提.阿合买提江 沈国华[1] 

机构地区：[1]中国石油天然气集团公司中心医院,河北廊坊065000 [2]新疆医科大学口腔医学系,新疆乌鲁木齐830000

出　　处：《临床口腔医学杂志》2012年第6期342-344,共3页Journal of Clinical Stomatology

摘　　要：目的:探讨凋亡相关蛋白Bcl-2在口腔扁平苔藓(OLP)病变中的生物学行为及对OLP皮损中浸润淋巴细胞聚集、分布的影响,进一步了解OLP的发病机制。方法:采用免疫组织化学检测法,与正常口腔黏膜对照,观察分析25例OLP皮损中Bcl-2蛋白的表达水平及淋巴细胞聚集、分布。结果:OLP病损区T细胞中Bcl-2过度表达,固有层淋巴细胞异常克隆、聚集,浸润增加。结论:OLP病损区中T细胞高密度聚集可能是Bcl-2诱导的局部淋巴细胞过度增殖后关联反应。Objective： To evaluate the accumahion, distribution of lymphocytic effected by biological behavior of cellular apoptosis protein for investigating pathogenesis in oral lichen planus, nethod：Immunohistochemical technique was used to observe and anlysis the expression of Bcl-2 occurred in lymphocyte in 25 cases of OLP compared with control group. Result： Bcl-2 overexpressed cause polycolnal expanion, ccumulation of infiltrating lymphocytes in OLP. Conclusion：The concentrated accumulation may be connective reaction to excessive proliferation of T lymphocyte activated by Bcl-2 in lesions of OLP.

关 键 词：口腔扁平苔藓 凋亡蛋白 

分 类 号：R781.5[医药卫生—口腔医学] R780.2[医药卫生—临床医学]