晚期NSCLC化疗患者68例营养状况及生活质量调查  

作　　者：陈永春[1] 许桢[2] 王自勤[3] 

机构地区：[1]河南省人民医院营养室,450003 [2]郑州人民医院营养科 [3]武警河南总队医院营养科,450052

出　　处：《当代医学》2012年第17期4-6,共3页Contemporary Medicine

摘　　要：目的调查评估晚期NSCLC化疗患者的营养状况及生活质量,为进一步开展该人群的针对性营养宣教和营养治疗提供依据。方法应用PG-SGA和QLQ-C30量表调查68例晚期NSCLC化疗患者的营养状况和生活质量,比较PG-SGA不同得分组患者的生活质量,以及不同疗效组患者化疗后的营养状态。结果 68例晚期NSCLC患者中,化疗前营养良好46例(67.2%),轻度或疑似营养不良17例(25.5%),重度营养不良5例(7.3%)。PG-SGA评分与PS评分、临床分期显著相关(P<0.05),而与年龄、性别、病理学类型无显著相关。4个疗程化疗结束时不同疗效组患者的营养状态不同,疾病进展组患者的重度营养不良比例最高(27.3%),部分缓解组患者营养良好的比例最高(66.6%),且差异有统计学意义(P<0.05)。营养良好的患者在躯体功能、角色功能、情绪功能、认知功能、疲倦、恶心、呕吐、失眠、食欲丧失、便秘、腹泻等方面优于营养不良的患者(P<0.05)。结论晚期NSCLC患者的营养不良发生率较高,化疗可加重营养不良程度。近期疗效、生活质量均与营养状态相关。良好的营养状况有可能提高晚期NSCLC化疗患者的生活质量;医护人员应该掌握简便、实用的营养评价工具,做好患者的健康教育,改善患者的营养状况,提高患者的生活质量。Objective To examine the nutritional status and quality of life of advanced non-small cell lung cancer（NSCLC） patients receiving chemotherapy,and provide customized schedule of nutrition support and intervention.Methods 68 patients with advanced NSCLC were enrolled for nutritional status and quality of life survey,including patient-generated subjective global assessment（PG-SGA）,quality of life-core30（QLQ-C30） the period of chemotherapy,to compare the quality of life among patients with different nutritional status,and the difference in nutritional status among patients with different clinical results.Results In 68 patients with advanced NSCLC,46（67.2%） patients were under good nutritional status,17（25.5%） patients had mild or suspected malnutrition,and 5（7.3%） patients had severe malnutrition.The Eastern Cooperative Oncology Group performance status（ECOG PS） score and clinical stage both are factors related to PG-SGA score（P〈0.05）,while the age,gender and pathology were not associated with PG-SGA score.After 4 cycles of chemotherapy,there were significant difference in nutritional status among patients with different clinical results（P〈0.05）,the incidence of severe malnutrition was highest in patients with progressive disease（27.3%）,and the ratio of good nutritional status was highest in patients with partial response（66.6%）.Good nutrition patients had advantage over malnourished patients in physical function,the role of function,emotional function,cognitive function,fatigue,nausea,vomiting,insomnia,loss of appetite,constipation and diarrhoea（P〈0.05）.Conclusion The malnutrition occurred in advanced NSCLC with a very high incidence,and the chemotherapy can strengthen the degree of malnutrition,which is related to clinical results and quality of life.Good nutrition may improve the quality of life of advanced NSCLC patients receiving chemotherapy.It is necessary for medical workers to master the simple and practical nutrition evaluation tools,provide high quality

关 键 词：非小细胞肺癌 化疗 营养状况 生活质量 

分 类 号：R734.2[医药卫生—肿瘤]