朊病毒感染途径的研究进展  

Recent Progress in Study of Prion Neuroinvasion

作　　者：王辉暖[1] 陈伯安[1] 周向梅[1] 尹晓敏[1] 杨利峰[1] 

机构地区：[1]中国农业大学动物医学院国家动物海绵状脑病实验室,北京100193

出　　处：《实验动物科学》2012年第2期58-63,共6页Laboratory Animal Science

摘　　要：朊病毒病是一类能够感染人和其他动物的神经退行性传染病,其致死率高达100%,到目前为止尚无有效的治疗方法,该疾病直接威胁着人和动物的生命安全及健康。目前普遍认为该病的致病因子是一种结构异常的朊蛋白(PrPSc),其主要入侵宿主的中枢神经系统,研究发现PrPSc主要通过消化系统、血液循环系统和外周神经系统途径进行复制并传播,然后进入中枢神经系统导致疾病发生。本文对PrPSc从外周组织器官入侵神经系统的途径进行综述,以理解朊病毒神经入侵的机制。Prion diseases, a type of neurodegenerative diseases which can spread in human and animals, have a worldwide death rate of 100% , and threaten to the life and health of human and animals. However, there is no effective therapy solution so far. PrP^sc, considered as the infectious agent of the prion diseases, is concentrated mainly in the central nervous system. Previous studies indicate that PrP^sc is able to replicate and transmit through the digestive ,the circulatory and the peripheral nervous systems, and then enters the central nervous system where diseases occur. To elucidate the mechanism of prion nervoinvasion,we reviewed the invasion routes of PrP^sc from the peripheral tissues and organs to the central nervous system.

关 键 词：朊病毒病 神经入侵 PRPSC 

分 类 号：S852.65[农业科学—基础兽医学]