胰腺癌中血管内皮生长因子C、D表达与血管淋巴管新生的关系  

Expression of vascular endothelial growth factors C,D and their relationships to lymphangiogenesis in pancreatic carcinomas

作　　者：李智峰[1] 李高强[1] 田云霄[2] 袁艳龙[2] 司华鹏[1] 陶丽[1] 

机构地区：[1]河北省邯郸市第一医院,河北邯郸056802 [2]河北省邯郸市中心医院,河北邯郸056802

出　　处：《中国医药导报》2012年第17期70-72,共3页China Medical Herald

基　　金：河北省科技厅科技支撑项目(项目编号:09276153)

摘　　要：目的探讨人胰腺癌组织中血管内皮生长因子C(VEGF-C)及血管内皮生长因子D(VEGF-D)的表达与血管淋巴管生成的关系。方法选用63例根治性手术切除的胰腺癌组织及13例正常胰腺组织,用免疫组织化学(Envi-sion法)检测VEGF-C及VEGF-D在胰腺癌中的表达,并免疫组织化学染色CD31显示计数癌周微血管密度(MVD)和微淋巴管密度(MLVD),进行统计学分析比较胰腺癌中VEGF-C、VEGF-D表达和癌周MVD/MLVD的关系。结果 VEGF-C及VEGF-D阳性表达产物主要见于癌细胞胞浆,胰腺癌周围组织中MVD/MLVD明显升高;胰腺癌中VEGF-C、VEGF-D表达与癌周MVD/MLVD升高呈正相关(P<0.05)。结论胰腺癌中VEGF-C与VEGF-D的表达增高,均具有促进胰腺癌的血管淋巴管增生、促进癌细胞转移的能力。选择性阻断VEGF-C或VEGF-D的促血管生成作用,对控制胰腺癌的淋巴道转移可能是一个有效的选择。Objective To determine vascular endothelial growth factor C（VEGF-C） and D expression in pancreatic carcinomas and the relationship of the expression of VEGF-C and VEGF-D with lymph angiogenesis.Methods The expression of VEGF-C and VEGF-D were detected by immunohistochemical method in 63 cases of radical resected specimen of pancreatic cancer.The microvessel density（MVD） and microlymphatic vessel density（MLVD） of tumor-surrounding tissue were detected by anti-CD31 immunostaining.The normal pancreatic tissue（13 cases） served as the control group.Statistical analysis was used to determine therelationship between the expression of VEGF-C and VEGF-D and MVD/MLVD.Results The expression of VEGF-C and VEGF-D were observed in the cytoplasm of carcinoma cell.The overexpression of VEGF-C and D in pancreatic carcinomas were correlated significantly with high MVD/MLVD of tumor-surrounding tissue（P 0.05）.Conclusion The overexpression of VEGF-C and D may be contribute to lymph angiogenesis and cancerometastasis.Inhibiting the effect of VEGF-C or VEGF-D maybe is an effective option to control lymphatic metastasis of pancreatic carcinomas.

关 键 词：胰腺癌 血管内皮生长因子D 血管内皮生长因子C 微血管密度 微淋巴管密度 

分 类 号：R735.9[医药卫生—肿瘤]