白花蛇舌草、金钱草、丹参和甘草的配伍抑菌效应研究  

Study on Antibacterial Efficacy of Hedyotis Diffusa, Loosestrife,Salvia and Licorice for Compatibility

作　　者：朱文娟[1] 林铁豪[1] 肖建光[1] 

机构地区：[1]广东省药品检验所,广东广州510180

出　　处：《今日药学》2012年第5期264-266,共3页Pharmacy Today

摘　　要：目的白花蛇舌草、金钱草、丹参和甘草,几种抑菌中药材配伍前后的抑菌效应的变化。方法采用体外抑菌试验,试管二倍稀释法,先测定各抑菌中药材的抑菌性,再对这几种中药材进行配伍,同法测定其抑菌效果。结果白花蛇舌草、金钱草、丹参和甘草配伍后,对细菌和霉菌抑菌的总体效果相当于几种药材中,抑菌性最强药材的抑菌效果;对酵母菌的总体抑菌作用,达到抑菌性最强药材抑菌效果的2倍。甘草的不同配伍比例(0,0.5,1),对整个配伍的抑菌效果无明显作用。结论 4种抑菌中药材配伍后,对细菌、霉菌和酵母菌抑菌作用有明显的协同效应。Objective To explore the change of bacteriostatic effect of Hedyotis diffusa, loosestrife, Salvia and licorice before and after compatibility. Methods The antimicrobial tests were studied by using tubes serial dilution method. The bacteriostasis of several Chinese herbal medicines was determined. Then the bacteriostasis of several Chinese herbal medicines compound was determined with the same method as well. Results In the compatibility of Hedyotis diffusa, loosestrife, Salvia and licorice, the overall inhibitory effect on bacteria and mold were as high as the strongest antibacterial herbs. Besides, the overall inhibitory effect on the yeast was twice higher than the strongest antibacterial herbs. Different proportions of licorice （0,0. 5, 1 ） almost had the same inhibitory effect on this compatibility. Conclusion The compatibility of antibacterial medicines, is significant changed in bacterial, mold and yeast inhibition with obvious synergies effect.

关 键 词：中草药 体外抑菌 配伍 协同效应 

分 类 号：R285[医药卫生—中药学]