Mc3和Mc5在溃疡性结肠炎癌变过程中的意义  

The Significance of Mc3 and Mc5 in the Process of in Ulcerative Colitis Cancerization

作　　者：孔祥云[1,2] 顾勇[1,3] 张永国[1] 沙素梅[1] 吴开春[1] 

机构地区：[1]第四军医大学西京消化病医院肿瘤生物学国家重点实验室,陕西西安710032 [2]西安市第一医院消化内科,陕西西安710032 [3]武警陕西总队医院消化内科,陕西西安710032

出　　处：《现代生物医学进展》2012年第15期2871-2875,共5页Progress in Modern Biomedicine

基　　金：卫生部行业科研专项项目(201002020)

摘　　要：目的:探讨Mc3和Mc5在溃疡性结肠炎-上皮内瘤变-癌变过程中的表达和临床意义。方法:利用免疫组化染色检测168例溃疡性结肠炎(UC)、溃疡性结肠炎伴上皮内瘤变(UC+IN)、结直肠癌(CRC)中Mc3和Mc5的表达情况,分析Mc3和Mc5的表达水平在溃疡性结肠炎-上皮内瘤变-癌变过程中变化趋势,探讨潜在的临床意义。结果:Mc3和Mc5在UC的表达阳性率分别为30%和29%,在UC+IN的阳性率分别是48%和46%,在CRC组的阳性率分别是91%和89%。统计分析发现,Mc3和Mc5在溃疡性结肠炎、上皮内瘤变和结直肠癌的表达逐渐增加,差异具有统计学意义(P<0.05)。结论:Mc3和Mc5在溃疡性结肠炎-上皮内瘤变-癌变过程中表达逐渐增加,检测Mc3及Mc5的表达有助于判断癌变风险,且Mc3和Mc5具有较好的一致性。Objective： To investigate the expression and clinical significance of Mc3 and Mc5 during the development and procession from ulcerative colitis（UC） to intraepithelial neoplasia（IN） to colorectal cancer（CRC）.Methods： Immunohistochemical staining was applied to evaluate the expression of Mc3 and Mc5 in the samples of ulcerative colitis（UC,n=66）,ulcerative colitis with intraepithelial neoplasia（UC＋IN,n=52） and colorectal cancer（CRC,n=50）.The expression changing tendencies were analyzed to explore the potential clinical significance.Results： The positive expression rates of Mc3 and Mc5 expression were 30% and 29% in UC,which were 48% and 46% in UC＋IN,91% and 89% in CRC.The expression level of Mc3 and Mc5 in UC,UC＋IN and CRC increased gradually and significantly（P0.05）.Conclusion： The expression level of Mc3 and Mc5 increased gradually from UC to UC with IN to CRC,which suggests testing the expression of Mc3 and Mc5 may help determine the risk of cancerization.

关 键 词：MC3 Mc5 溃疡性结肠炎 上皮内瘤变 结直肠癌 

分 类 号：R574.62[医药卫生—消化系统] R735.2[医药卫生—内科学]