胃癌患者紧密连接蛋白1的表达及意义  

Expression of Zonula Occludens-1(ZO-1) in Gastric Cancer and Its Significance

作　　者：杨巍[1] 谷小虎[1] 苏晓晖[1] 郑志超[1] 赵岩[1] 

机构地区：[1]辽宁省肿瘤医院,辽宁沈阳110042

出　　处：《肿瘤学杂志》2012年第4期250-253,共4页Journal of Chinese Oncology

摘　　要：[目的]研究胃癌组织中紧密连接蛋白1（ZO-1）的表达及意义。[方法]采用免疫组织化学方法检测辽宁省肿瘤医院2001年1月~2006年12月期间收集的50例正常胃组织和100例胃癌及其癌旁组织标本中ZO-1表达情况,并分析胃癌组织中ZO-1表达水平与各临床参数之间的关系。[结果]ZO-1在胃癌组织中表达下调,在胃癌组织中的表达率（40.0%）显著低于癌旁组织（84.0%）和正常胃组织（84.0%）（P=0.000）。ZO-1表达水平与胃癌患者年龄、性别和组织学类型无关（P均〉0.05）。ZO-1表达水平与分化程度、浸润深度、区域淋巴结转移、远处转移及临床分期具有相关性,分化程度越低、浸润越深、伴有淋巴结转移和远处转移、临床分期越高,ZO-1表达水平越低（P均〈0.05）。ZO-1高表达组5年生存率高于低表达组（70%vs20%,P〈0.05）。[结论]ZO-1在胃癌组织中表达下调,与肿瘤的临床分期、转移和预后密切相关,可作为胃癌诊断和预后评价的标志物之一。[Purpose] To investigate the expression of zonula occludens-1（ZO-1） in gastric cancer tissue and its clinical significance.[Methods] The expression of ZO-1 in 50 cases of normal gastric tissues,100 cases of gastric cancer tissues and cancer adjacent tissues was detected immunohistochemically.The relationship between ZO-1 expression in gastric tissues and clinical parameters was analyzed.[Results] The expression of ZO-1 was downregulated in gastric cancer tissues.ZO-1 expression in gastric cancer（40.0%）was significantly lower than that in cancer adjacent tissues（84.0%） or normal gastric tissues（84.0%）（P=0.000）.The expression of ZO-1 did not correlate with age,gender and histologic type（P0.05）.It correlated with the degree of differentiation,depth of invasion,regional lymph node metastasis,distant metastasis and clinical stage.The lower differentiation grade,or deeper invasion,or regional lymph node metastasis,or distant metastasis,or higher clinical stage,the lower the expression of ZO-1（P0.05）.The 5-year survival rate of patients with a high expression of ZO-1 was significantly higher than that in patients with low expression（70.0% vs 20%,P0.05）.[Conclusions] ZO-1 expression down-regulates in gastric cancer and correlates with clinical stage,metastasis and prognosis.It may be as a biomarker to diagnosis and prognosis for gastric cancer.

关 键 词：胃肿瘤 紧密连接蛋白1 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]