帕洛诺司琼在局部晚期鼻咽癌同步放化疗中止吐作用研究  

The Efficacy of Palonosetron for Prevention of Concurrent Radiochemotherapy Induced Nausea and Vomit in Patients with Locally Advanced Nasopharyngeal Carcinoma

作　　者：童琴[1] 何振宇[2] 孙家媛[2] 李凤岩[2] 管迅行[2] 

机构地区：[1]南华大学附属第一医院,湖南衡阳421001 [2]华南肿瘤学国家重点实验室,中山大学肿瘤防治中心,广东广州510060

出　　处：《肿瘤学杂志》2012年第4期277-280,共4页Journal of Chinese Oncology

摘　　要：[目的]观察帕洛诺司琼在局部晚期鼻咽癌同步放化疗中的止吐疗效。[方法]54例采用每周顺铂方案进行同步放化疗的局部晚期鼻咽癌患者随机分为帕洛诺司琼组和托烷司琼组,比较两组患者恶心、呕吐及其他不良反应的发生情况。[结果]帕洛诺司琼组和托烷司琼组急性恶心和急性呕吐发生率无明显差异(P>0.05);而延迟性恶心和呕吐发生率帕洛诺司琼组(78.91%、62.50%)均低于托烷司琼组(88.37%、80.62%)(P<0.05)。其他不良反应包括便秘、腹胀、头痛及头晕,两组无明显差异(P>0.05)。[结论]帕洛诺司琼能有效预防局部晚期鼻咽癌同步放化疗引起的恶心呕吐,尤其对迟发性呕吐有较好的治疗效果。[Purpose] To investigate the efficacy of palonosetron for prevention of concurrent radiochemotherapy induced nausea and vomit in patients with locally advanced nasopharyngeal carcinoma.[Methods] Fifty-four cases with locally advanced nasopharyngeal carcinoma were randomly divided into palonosetron group and tropisetron group.The incidence rates of nausea,vomit and other side effects were observed and calculated.[Results] Incidence rates of acute nausea and acute vomit had no significant difference between palonosetron group and tropisetron group（P0.05）,while the incidence rates of chronic nausea and chronic vomit were lower in palonosetron group（78.91% and 62.50%） than that in tropisetron group（88.37% and 80.62%）（P0.05）.The other side effects including constipation,abdominal distension,headache and dizziness had no significant difference between the two groups（P0.05）.[Conclusion] Palonosetron is effective for prevention of nausea and vomit induced by concurrent radiochemotherapy in patients with locally advanced nasopharyngeal carcinoma,especially for prevention of chronic nausea and vomit.

关 键 词：帕洛诺司琼 托烷司琼 止吐 鼻咽肿瘤 

分 类 号：R739.62[医药卫生—肿瘤]