A clinical study of Weining Granules in the treatment of gastric precancerous lesions  

作　　者：邓鑫 刘振威 吴发胜 李龙华 梁健 

机构地区：[1]Guangxi Traditional Chinese Medical University [2]The First Hospital,Jiangxi University of Traditional Chinese Medicine

出　　处：《Journal of Traditional Chinese Medicine》2012年第2期164-172,共9页中医杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.81160433);Guangxi Traditional Chinese Medicine Administration Foundation(No.GZYZ-10-18)

摘　　要：OBJECTIVE:To investigate the clinical effects of Weining Granules on gastric precancerous lesions(GPLs).METHODS:120 patients with GPLs were randomly assigned in a 1:1 ratio to receive Weining Granules(trial group) or the comparator Weifuchun tablets(control group) for 6 months.Outcomes were compared between the two groups including:overall response;gastroscopically-determined response;pathologically-confirmed response;eradication of Helicobacter pylori(HP);microvessel density(MVD) in the gastric mucosa;expression of vascular endothelial growth factor(VEGF);interleukin 2(IL-2);interleukin 6(IL-6);T lymphocyte subsets;immunoglobulins;symptom scores;quality of life(QOL);and adverse reactions.RESULTS:Patients in the trial group had a significantly higher(P<0.05) overall response rate(81.7%) as compared with those in the control group(63.3%).Relative to treatment with Weifuchun tablets treatment with Weining Granules resulted in a significant improvement(P<0.05) in the scores for gastric pain,distension and stuffiness in the hypochondrium,and anorexia.As compared with the tablets the Granules were associated with a significantly higher overall gastroscopically-determined response rate(78.3%;P<0.05).Pathological examination of tissue samples indicated that 61.7% of patients receiving the granules were cured with an overall response rate of 75.5%;these rates were significantly higher than in the control group(P<0.05).In comparison with patients receiving the tablets,those given the granules were significantly more likely to have their HP eradicated(75.0% vs.51.4%;P<0.05).Improvements in MVD,VEGF,CD4+,CD4+/CD8+,IL-2,IL-6 and IgG were significantly greater with the Weining Granules than with the Weifuchun tablets(P<0.05 or P<0.01).After follow-up of 1 year,17.5% of patients in the trial group relapsed as compared with 39.5% in the control group(P<0.05).Relative to the control group,the trial group showed significantly greater improvements in physical,psychological and social relationships,and in environmental domains(P<0.OBJECTIVE：To investigate the clinical effects of Weining Granules on gastric precancerous lesions（GPLs）.METHODS：120 patients with GPLs were randomly assigned in a 1：1 ratio to receive Weining Granules（trial group） or the comparator Weifuchun tablets（control group） for 6 months.Outcomes were compared between the two groups including：overall response;gastroscopically-determined response;pathologically-confirmed response;eradication of Helicobacter pylori（HP）;microvessel density（MVD） in the gastric mucosa;expression of vascular endothelial growth factor（VEGF）;interleukin 2（IL-2）;interleukin 6（IL-6）;T lymphocyte subsets;immunoglobulins;symptom scores;quality of life（QOL）;and adverse reactions.RESULTS：Patients in the trial group had a significantly higher（P〈0.05） overall response rate（81.7%） as compared with those in the control group（63.3%）.Relative to treatment with Weifuchun tablets treatment with Weining Granules resulted in a significant improvement（P〈0.05） in the scores for gastric pain,distension and stuffiness in the hypochondrium,and anorexia.As compared with the tablets the Granules were associated with a significantly higher overall gastroscopically-determined response rate（78.3%;P〈0.05）.Pathological examination of tissue samples indicated that 61.7% of patients receiving the granules were cured with an overall response rate of 75.5%;these rates were significantly higher than in the control group（P〈0.05）.In comparison with patients receiving the tablets,those given the granules were significantly more likely to have their HP eradicated（75.0% vs.51.4%;P〈0.05）.Improvements in MVD,VEGF,CD4＋,CD4＋/CD8＋,IL-2,IL-6 and IgG were significantly greater with the Weining Granules than with the Weifuchun tablets（P〈0.05 or P〈0.01）.After follow-up of 1 year,17.5% of patients in the trial group relapsed as compared with 39.5% in the control group（P〈0.05）.Relative to the control group,the trial group showed significantly g

关 键 词：Gastric precancerous lesions Weining Granules Weifuchun Tablets Clinical study 

分 类 号：R735[医药卫生—肿瘤]