介入性肝动脉插管栓塞化疗术治疗肝癌肝移植术后肿瘤肝内复发的应用研究  

Transcatheter arterial chemoembolization in treatment of intrahepatic recurrence following liver transplantation for hetatocellular carcinoma

作　　者：赵洪强[1] 李为民[2] 郑方[2] 刘浩润[2] 杜继东[2] 

机构地区：[1]解放军总医院军医进修学院,北京100853 [2]解放军第309医院肝胆一科

出　　处：《临床外科杂志》2012年第4期257-259,共3页Journal of Clinical Surgery

摘　　要：目的 观察介入性肝动脉插管栓塞化疗术（TACE）治疗肝癌肝移植术后肿瘤肝内复发的疗效及其安全性.方法 28例接受TACE治疗的肝癌肝移植术后癌肿复发患者组成TACE组.同期26例未使用TACE及其他抗肿瘤治疗的肝癌肝移植术后癌肿复发患者为对照组.分析其生存情况,血清肿瘤标志物变化,不良反应等,并记录TACE治疗后肿瘤坏死程度,分析TACE治疗效果.结果 TACE组中位生存时间较对照组明显延长（P〈0.01）.TACE组治疗后较治疗前AFP明显下降（P〈0.05）,而对照组入组1个月后AFP值较入组时显著增加（P〈0.05）.TACE治疗能使肿瘤呈大部分坏死,显著降低肿瘤负荷.结论 TACE治疗肝癌肝移植术后癌症复发患者能获得较好疗效,且并发症少,值得临床推广.Objective To investigate the effect and the security of transcatheter arterial chemo- embolization（TACE） in the treatment of intrahepatic recurrence following liver transplantation for hepato-cellular carcinoma （HCC）. Methods Twenty-eight patients who received TACE for intrahepatie recur-rence following liver transplantation for HCC were allocated to TACE group; 26 simultaneous patients who did not receive any anti-tumor treatment after intrahepatic recurrence were allocated to the control group. Patients＂ baseline, survival data, serum tumor markers, adverse reactions and the necrosis degree of the fo- cus were recorded and compared. All these were contributed to the analysis of the effect of TACE. Results The difference of the baseline between both groups was not significant （ P 〉 0.05 ）. The median survival time of TACE group was longer than that of the control group（ P 〉 0.05 ）. The serum AFP level decreased after the treatment in the TACE group （ P 〉 0.05 ）, while increased in the control group one month later. The treatment of TACE can lead to necrosis of most parts of the tumor focus. Conclusion The treatment of TACE is a safe and minimally invasive procedure which is strongly recommended for intrahepatic recur-rence following liver transplantation for HCC.

关 键 词：介入性肝动脉插管栓塞化疗术 肝移植 肝癌 复发 

分 类 号：R735.7[医药卫生—肿瘤]