肿瘤患者个体化检测化疗的疗效观察  

Therapeutic Effect of Tumor Patients after Chemotherapy According to the Personalized Test

作　　者：郭双双[1] 马文静[1] 张立成[1] 孙文俏[1] 

机构地区：[1]山东省泰安市解放军第88医院肿瘤中心一区,271000

出　　处：《实用癌症杂志》2012年第3期292-294,共3页The Practical Journal of Cancer

摘　　要：目的探讨根据肿瘤患者个体化检测结果,选择预期敏感药物进行化疗的有效性。方法观察32例肿瘤患者,根据个体化检测结果进行化疗后的疗效、生活质量、不良反应及生存率。结果 32例患者中CR 15.6%(5/32),PR 46.8%(15/32),SD 25.0%(8/32),PD 12.5%(4/32),客观有效率为65.6%(21/32),疾病控制率为87.5%(28/32)。治疗结束后肿瘤标志物水平16例降至正常,9例呈下降趋势,但尚未降至正常,4例无明显变化,3例较治疗前水平升高。所有患者均未出现严重不良反应,治疗后KPS评分明显升高,与治疗前相比差异有统计学意义(P<0.05),治疗后患者饮食及体重增长率分别为71.9%(23/32)和59.4%(19/32)。2例患者因病情进展而死亡。结论根据个体化检测结果进行化疗可明显提高疗效,减轻不良反应。Objective To investigate the therapeutic effect of tumor patients after chemotherapy who chose the expected sensitive drugs according to the personalized test. Methods Thirty-two tumor patients were selected to observe the therapeutic effect, the quality of life, adverse reactions and survival rates after chemotherapy according to the personalized test. Results Of the 32 treated patients, the CR rate was 15.6% （5/32）, the PR rate was 46.8% （ 15/32）, the SD rate was 25.0% （8/32）and the PD rate was 12.5% （4/32）. The objective response rate and disease control rate were 65.6% and 87.5% respectively. After the treatment,the serum levels of tumor marker declined to normal level in 16 cases and declined significantly but not yet reached normal level in 9 cases,had no evident change in 4 cases and in the remaining 3 cases. No serious adverse reaction was observed in patients, and the karnofsky score increased significantly （ P 〈 0.05 ）, The body weight and dietary growth rate were 71.9% and 59.4% respectively. Two patients were died because of disease progression. Conclusion Tailored medication for tumor patients can improve curative effect, and reduce side effect.

关 键 词：肿瘤 个体化检测 化疗 

分 类 号：R730.5[医药卫生—肿瘤]