手法治疗实验性膝骨关节炎扫描电镜研究  

Electronmicroscopic Study of Mamipulation on Experimental Model of Osteoarthritis

作　　者：张昊[1] 杜宁[1] 任峰[1] 张凤华[1] 史炜镔[1] 

机构地区：[1]上海市第二医科大学附属瑞金医院,上海200025

出　　处：《中国中医骨伤科杂志》2000年第2期1-3,共3页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：国家自然科学基金资助!编号 :39770 92 0

摘　　要：目的 :观察手法防治兔膝骨关节炎扫描电镜下超微结构的变化 ,评价手法治疗的效果。方法 :采用结扎股静脉 ,臀下静脉方法造成兔骨内高压膝关节骨关节炎模型 ,术后第二天进行手法治疗 ,每日 3次。同时设立正常组和模型组。分别于术后 8、12、16、2 0周取材。扫描电镜观察胫骨内髁关节软骨超微结构的变化。结果 :实验组骨关节炎改变较对照组明显减轻。结论Objective:To evaluate the effect of manipulation on experimental model of Osteoarthritis (OA).Methods:27 adult New Zealand rabbits were involved as high intraosseous pressure experiment model by ligating the vena femoralis and gluteae inferiores.Then the model OA keens were treated with manipulation every day postoperatively.At the same time,the model control group and the normal control group were set.The animals were sacrificed at 8,12,16,20 weeks after the operation.The medial tibia condyle was excised and processed for scan electronmicroscopic study.Results:There was a significant delay and lessening of the degenerative changes of articular cartilage in experimental group.Conclusion:The findings of this experiment indicated that manipulation can alleviate the degeneration of cartilage and it should be applied as an effective method of treating OA.

关 键 词：手法 膝骨关节炎 超微结构 扫描电镜 

分 类 号：R684.3[医药卫生—骨科学]