PAMAM作为抗肿瘤药物载体研究进展  

Study on the Development of PAMAM as a New Type of Anticancer Drug Carrier

作　　者：张赛群[1] 彭剑青[1] 

机构地区：[1]贵阳医学院药学院,贵阳550004

出　　处：《数理医药学杂志》2012年第3期355-358,共4页Journal of Mathematical Medicine

基　　金：国家中医药管理局特别科技研究基金(No.06-07ZP21)资助项目

摘　　要：树枝状大分子是一类新型的高分子材料,具有高度枝化、结构可控、单分散等特点,其中聚酰胺-胺型大分子(Poly-amidoamine,PAMAM)由于能提高药物的水溶性、靶向性和生物利用度,已在抗肿瘤药物载体领域有着广泛的应用。本文将就PAMAM作为一种新型的抗肿瘤药物载体的研究进展进行综述。Dendrimers are new class of polymeric materials, generally described as a macromolecule which is characterized by its high degree of branching, well-defined molecular structure and monodispersity. Polyamidoamine（PAMAM） is one of the most widely investigated dendrimers, which has been used as an i- deal carrier in anticancer-delivery systems, which can increase water solubility, targeting activity and bioavailability of drugs. This review demonstrated the studying development of PAMAM as a new anticancer carrier.

关 键 词：PAMAM 抗肿瘤药物 靶向 载体 

分 类 号：R979.1[医药卫生—药品]