血清VEGF-A及其受体VEGFR-2水平与鼻咽癌患者淋巴转移的关系  

Relationship Between Serum VEGF-A,VEGFR-2 and Lymph Node Metastasis in Nasopharyngeal Carcinoma

作　　者：邹容[1] 赵萍萍[1] 陈熙[1] 屈元姣[1] 曹轶林[1] 刘陶文[1] 

机构地区：[1]广西壮族自治区南溪山医院肿瘤科,广西桂林541002

出　　处：《肿瘤基础与临床》2012年第3期204-207,共4页journal of basic and clinical oncology

基　　金：广西科学研究与技术开发计划项目(编号:桂科攻0322025-4);桂林市科学研究与技术开发计划项目(编号:20080403)

摘　　要：目的探讨鼻咽癌患者血清血管内皮生长因子-A(VEGF-A)及血管内皮生长因子受体2(VEGFR-2)水平在鼻咽癌淋巴转移中的意义。方法采用ELISA法检测68例鼻咽癌患者和20例健康对照者血清VEGF-A和VEGFR-2水平,并分析这些指标变化的意义。结果初治及复发组鼻咽癌患者血清VEGF-A、VEGFR-2水平明显高于健康对照组及完全缓解组(P均<0.05)。血清VEGF-A和VEGFR-2水平与鼻咽癌T分期及N分期均有关(P均<0.05)。有淋巴转移的鼻咽癌患者血清VEGF-A和VEGFR-2水平明显高于无淋巴转移患者(P<0.05)。32例初治鼻咽癌患者血清VEGF-A与VEGFR-2水平呈正相关(r=0.810,P<0.05)。结论高水平的血清VEGF-A、VEGFR-2在鼻咽癌发展中起重要作用,能促进鼻咽癌发生淋巴转移。Objective To explore the significance of serum VEGF-A and VEGFR-2 levels in relation with lymph node metastasis of nasopharyngeal carcinoma. Methods The 68 patients with nasopharyngeal carcinoma and 20 healthy controls were included in the current study. Serum VEGF-A and VEGFR-2 levels were assessed by ELISA. Results Serum VEGF-A and VEGFR-2 levels of the untreated and recurrent patients were significantly higher than those of the heathy controls and the patients complete remission （P 〈 0.05）. Serum VEGF-A and VEGFR-2 levels were correlated with T stage and N stage（ P 〈 0.05 ）. Serum VEGF-A and VEGFR-2 levels of nasopharyngeal carci- noma patients with lymph node metastasis were significantly higher than those of patients without lymph node metas- tasis. For the serum VEGF-A was positively related with VEGFR-2 （ r = 0. 810, P 〈 0.05 ）. Conclusion High levels of serum VEGF-A and VEGFR-2 play an important role in the department of nasopharyngeal carcinoma, and may promote lymph node metastasis of nasopharyngeal carcinoma.

关 键 词：鼻咽癌 血管内皮生长因子-A 血管内皮生长因子受体-2 酶联免疫吸附试验 

分 类 号：R739.63[医药卫生—肿瘤]