周剂量奥沙利铂联合替吉奥一线治疗老年晚期胃癌的临床观察  

Weekly Oxaliplatin plus S-1 as a First Line Chemotherapy for Elderly Patients with Advanced Gastric Cancer

作　　者：姜勇[1] 崔林[1] 吴兴军[1] 刘兴祥[1] 周向荣[1] 刘建军[1] 何学军[1] 李阳[1] 

机构地区：[1]姜堰市人民医院肿瘤科,江苏姜堰225500

出　　处：《肿瘤基础与临床》2012年第3期208-210,共3页journal of basic and clinical oncology

摘　　要：目的探讨周剂量奥沙利铂(L-OHP)联合替吉奥(S-1)作为一线治疗方案治疗老年晚期胃癌的疗效和安全性。方法 24例有可测量病灶的老年晚期胃癌患者采用L-OHP联合S-1治疗,以3周为1周期,至少连用2周期以上评价疗效和毒副反应。结果全组24例患者均可评价疗效,其中CR 0例,PR 10例,SD 6例,PD 8例,客观有效率为41.67%,疾病控制率66.67%。中位疾病进展时间为5个月。中位缓解期8个月。毒副反应主要是骨髓抑制和恶心呕吐,均为可逆性。结论周剂量L-OHP联合S-1一线治疗老年晚期胃癌的近期疗效肯定,安全性较好。Objective To evaluate the effect and toxicities of weekly oxaliplatin （L-OHP） plus S-1 as a first line chemotherapy regimen for elderly patients with advanced gastric cancer. Methods Twenty-four elderly patients with advanced gastric cancer received the L-OHP plus S-1 chemotherapy,3 weeks were 1 cycle, and the effect and toxici- ties were evaluated after 2 cycles of chemotherapy. Results Of all the 24 patients could be evaluated, CR was observed in the 0 patient, PR in the 10 patients, SD in the 6 patients, PD in the 8 patients, the overall response rate was 41.67% ,the disease control rate was 66.67%. The median time to tumor progression was 5 months. The median duration of remission was 8 months. The major toxicities were bone marrow suppression, nausea and vomiting. Conclusion Weekly oxaliplatin plud S-1 is effective and safe as a first line regimen for elderly patients with advanced gastric cancer.

关 键 词：L-OHP 替吉奥 晚期胃癌 化疗 

分 类 号：R735.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]