产前慢性缺氧对子代大鼠血压的影响  

Blood pressure of rat offspring associated with prenatal chronic hypoxia

作　　者：应红安[1] 洪卫文[2] 童鸿[1] 黄子扬[3] 

机构地区：[1]台州市第一人民医院心内科,浙江台州318020 [2]台州市第一人民医院普外科,浙江台州318020 [3]福建医科大学附属第二医院,福建泉州362000

出　　处：《岭南心血管病杂志》2012年第3期298-302,共5页South China Journal of Cardiovascular Diseases

摘　　要：目的研究产前慢性缺氧对子代大鼠血压的影响。方法25只SD大鼠孕鼠,按电脑随机数字表法均分为4个妊娠期缺氧组(早期缺氧组、中期缺氧组、晚期缺氧组、全期缺氧组)和1个对照组。出生子代大鼠分别于1个月龄、3个月龄、6个月龄每组电脑随机数字表法取雌雄子鼠各5只,分别选用无创血压仪检测子鼠血压及心率。结果各组心率比较,差异无统计学意义(P>0.05)。各缺氧组子代大鼠1个月龄血压与对照组比较,差异无统计学意义(P>0.05);3个月龄较对照组明显升高,6个月龄升高更加显著,差异均有统计学意义(P<0.05),以妊娠中期缺氧的雄性子代升高最为明显[(136.80±2.18)mm Hg vs.(110.20±2.18)mm Hg,P<0.05]。结论妊娠期慢性缺氧可致成年子代大鼠血压升高,以雄性子代血压升高更明显。Objectives To explore the effects of prenatal chronic hypoxia on blood pressure in rat offspring. Methods Twenty five pregnant SD rats were divided randomly into 5 groups： 4 prenatal chronic hypoxia groups （early, middle, late and whole hypoxia group） and 1 control group. Five male and 5 female offsprings of each group were randmnly selected to study when the descendant rats were 1 month, 3 months and 6 months old respectively. Blood pressures and heart rates of the rat offsprings were measured by noninvasive blood pressure monitor. Results Heart rates had no significant differences among all the groups （P〉O.05）. There was no significant difference between blood pressure of 1-month-old offsprings in chronic hypoxia groups and that in control group （P〉0.05）. Blood pressure of 3-month-old oflsprlngs in hypoxia groups were significantly higher than that in control group, and became even higher when they were 6 months old （P〈0.05）. Blood prcssure of male offsprings in middle bypoxia group was the highest [ （136.80±2.18） mm Hg vs. （110.20±2.18） mm Hg,P〈O.05 ]. Conclusions Chronic hypoxia during pregnancy can elevate blood pressure of aduh rat offspring, especially for male rat offspring.

关 键 词：缺氧 血压 心率 妊娠 大鼠 

分 类 号：R364.4[医药卫生—病理学]