大剂量苯巴比妥治疗难治性惊厥性癫痫持续状态的临床观察  

Clinical observation of the outcome of patients withintractable status epilepticus treated by high-dosage of phenobabital

作　　者：任思颖[1] 伍国锋[1] 毛远红[1] 熊洁[1] 罗兴梅[1] 许兰[1] 陈镭[1] 

机构地区：[1]贵州省紧急救援中心,贵阳医学院急诊医学教研室,贵州贵阳550004

出　　处：《癫痫与神经电生理学杂志》2012年第3期144-148,F0003,共6页Journal of Epileptology and Electroneurophysiology(China)

摘　　要：目的：观察大剂量苯巴比妥治疗难治性癫痫持续状态（SE）的效果，企为临床工作提供参考。方法：对急诊人院的21例以全身惊厥性SE为突出症状的患者，在针对病因进行积极治疗的同时，进行常规抗癫痫药物（AED）静脉滴注，若癫痫发作症状难以控制则改用大剂量苯巴比妥进行治疗，观察分析其治疗效果。结果：常规AED治疗时，患者24h内癫痫缓解率为20％；没有完全控制者，改用大剂量苯巴比妥静脉滴注后24h内癫痫均得到完全控制。结论：大剂量苯巴比妥治疗难治性SE是安全有效的方法，常规治疗方法无效时可以采用该方法进行治疗。Objective：To observe the therapeutic effect of high-dosage of phenobatital in the treatment of patients with intractable status epilepsy （SE）, so as to provide references for clinical practice. Methods： Twenty one patients with intractable convulsive SE were emergently admitted into our hospital and regular antiepileptie drugs （AEDs） were dripped intravenously to treat these patients. If the symptoms could not be controlled, the high-dosage phenobabital therapy was performed and the therapeutic effect was analyzed. Results：The remission rate of seizures within 24 hours was 20% as regular AEDs were administered. No seizure-free patients were observed. When high-dosage phenobabital therapy was used, the seizures were controlled successfully. All the patients were seizure-free within 24 hours after high-dosage phenohabital therapy. Conclusion： High-dosage phenobabital therapy is effective and safe in the treatment of intractable SE. It may be performed after regular therapy fails to control the SE.

关 键 词：癫痫持续状态(SE) 抗癫痫药物(AED) 苯巴比妥疗法 

分 类 号：R742.1[医药卫生—神经病学与精神病学]