注射用头孢地秦钠与注射用氯诺昔康配伍稳定性考察  

Compatible stability of cefodizime sodium and lornoxicam in 0.9% sodium chloride

作　　者：陈富超[1] 方宝霞[1] 朱军[1] 李鹏[1] 杨盼鑫[2] 

机构地区：[1]湖北医药学院附属东风医院药学部,湖北十堰442008 [2]湖北医药学院药学院,湖北十堰442000

出　　处：《中南药学》2012年第5期364-367,共4页Central South Pharmacy

摘　　要：目的考察注射用头孢地秦钠与注射用氯诺昔康在0.9%氯化钠注射液中的配伍稳定性。方法在(25±1)℃下,采用高效液相色谱法(HPLC)测定配伍液8h内头孢地秦钠与氯诺昔康的含量变化,并观察和检测配伍液的外观、pH值及不溶性微粒变化,结果在室温下配伍液8h内的含量、pH、不溶性微粒及外观均无明显变化。结论室温条件下,注射用头孢地秦钠与注射用氯诺昔康在0.9%氯化钠注射液中8h内稳定。Objective To determine the stability and compatibility of cefodizime sodium with lornoxicam in 0.9~ sodi- um chloride injection. Methods HPLC method was used to determine the change of content after combination of cefo- dizime sodium with lornoxicam in 0. 9 % sodium chloride injection under （25 4-1）℃ within 8 h. The appearance and particle of the solution were observed and the pH value was measured. Results No significant differences were found in the content, appearance, particle and pH value of the mixture within 8 h at room temperature. Conclusion The mixture of cefodizime sodium with lornoxicam in 0. 9 h. sodium chloride injection at room temperature is stable within 8 h.

关 键 词：头孢地秦钠 氯诺昔康 高效液相色谱法 配伍 稳定性 

分 类 号：R969.3[医药卫生—药理学]