奥沙拉秦对慢性溃疡性结肠炎患者血清肿瘤坏死因子α、白细胞介素10影响的研究  

The study of the influence of olsalazine on tumor necrosis factor-alpha and interleukin-lO in patients with chronic ulcerative colitis

作　　者：任杰远[1] 李书敏[1] 俎蕊[1] 张秋芹[1] 张政[1] 

机构地区：[1]山东省滨州市中心医院消化内科,251700

出　　处：《中国医师进修杂志》2012年第16期17-19,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨奥沙拉秦对慢性溃疡性结肠炎患者血清肿瘤坏死因子α（TNF-α）、白细胞介素10（IL-10）的影响。方法共纳入60例慢性溃疡性结肠炎患者（病例组），其中慢性复发性患者22例，慢性持续性患者38例，均给予奥沙拉秦治疗，同时从门诊随机抽取60例无溃疡性结肠炎病史者作为对照组。应用免疫透射比浊法检测两组血清TNF-α、IL-10的含量并比较。结果病例组治疗前血清TNF-α含量明显高于对照组[（57．2±10．1）ng／L比（27．2±6．9）ng／L]，而IL-10含量明显低于对照组[（9．2±2．1）ng／L比（17．3±2．9）ng／L]，差异有统计学意义（P〈0．05）；病例组慢性持续性患者与慢性复发性患者治疗前TNF-α含量[（56．9±9．9）、（57．3±9．7）ng／L]明显高于对照组，而IL-10含量[（9．1±2．3）、（8．4±2．5）ng／L]明显低于对照组，差异有统计学意义（P〈0．05）。病例组治疗后血清TNF-α含量明显低于治疗前[（28．1±8．9）ng／L比（57．2±10．1）ng／L]，而IL-10含量明显高于治疗前[（13．4±10．7）ng／L比（9．2±2．1）ng／L]，差异有统计学意义（P〈0．05）；慢性持续性患者及慢性复发性患者治疗前后血清TNF-α、IL-10含量比较差异有统计学意义（P〈0．05）。结论奥沙拉秦可显著降低慢性溃疡性结肠炎患者血清TNF-α含量，增加血清IL-10含量，有临床应用价值。Objective To investigate the influence of olsalazine on tumor necrosis factor-alpha （TNF-α ） and interleukin-10 （IL-10） in patients with chronic ulcerative colitis. Methods Sixty patients with chronic ulcerative colitis （observation group）,including 22 chronic recurrent cases and 38 chronic persistent cases, were enrolled and treated with olsalazine. Meanwhile, 60 healthy volunteers without disease history of ulcerative colitis were selected as control group. The concentrations of TNF-α and IL-10 in serum of the two groups were detected by ELISA and compared. Results Before treatment ,t he concentration of TNF-α in serum of the observation group was significantly higher than that of control group [ （ 57.2 ± 10.1 ） ng/L vs. （27.2 ±6.9） ng/L] ,while IL-10 was significantly lower than that of control group[ （9.2 ± 2.1 ） ng/L vs. （17.3 ± 2.9） ng/L] （P 〈 0.05）. Before treatmen t, the concentration of TNF-α in serum in chronic persistent patients and chronic recurrent patients [ （56.9 ± 9.9 ）, （57.3 ± 9.7 ） ng/L ] were significandy higher than that in control group,and serum IL-IO in chronic persistent patients and chronic recurrent patients [ （ 9.1 ± 2.3 ）, （ 8.4 ± 2.5 ） ng/L ] was significantly lower than that in control group （ P 〈 0.05 ）. The concentration of TNF-α in serum in observation group after treatment was obviously lower than that before treatment [ （28.1 ± 8.9） ng/L vs. （57.2 ± 10.1 ） ng/L],and IL-10 was obviously higher than that before treatment [ （ 13.4 ± 10.7 ） ng/L vs. （ 9.2 ± 2.1 ） ng/L ] （ P 〈 0.05 ）. The concentration of serum TNF-α and IL- 10 in chronic persistent and chronic recurrent patients before and after treatment had statistical significance （P 〈 0.05）. Conclusions Olsalazine can significantly decrease the concentration of TNF-α and increase the concentration of IL-10 in serum in patients with chronic ulcerative colitis. It is worthy of application in clinic.

关 键 词：结肠炎 溃疠性 肿瘤坏死因子Α 白细胞介素10 奥沙拉秦 

分 类 号：R574.62[医药卫生—消化系统]