细胞外信号调节激酶在血管瘤组织中的表达及活性  

Expression and activation of extracellular signal regulated kinase in hemangioma

作　　者：冯进云[1] 李萍[1] 江贤萍[2] 彭振辉[3] 

机构地区：[1]深圳市儿童医院皮肤科,广东深圳518026 [2]深圳市儿童医院病理科,广东深圳518026 [3]西安交通大学第二医院皮肤科,陕西西安710004

出　　处：《中国美容医学》2012年第7期1163-1165,共3页Chinese Journal of Aesthetic Medicine

基　　金：深圳市科技计划项目(编号:201003140)

摘　　要：目的:探讨细胞外信号调节激酶1/2(ERK1/2)及其活性形式磷酸化ERK1/2(p-ERK1/2)在血管瘤组织中的蛋白表达及其意义。方法:应用免疫组织化学SP法,检测23例增生期血管瘤组织及19例退化期血管瘤组织ERK1/2和p-ERK1/2的蛋白表达。结果:增生期血管瘤组织与退化期血管瘤组织ERK1/2的蛋白表达无统计学差异(Z=-0.305,P>0.05);增生期血管瘤组织p-ERK1/2的蛋白表达显著高于退化期血管瘤组织的表达(Z=-4.271,P<0.01)结论:增生期血管瘤组织p-ERK1/2呈高表达,血管瘤的增生与ERK通路的激活有关。Objective To investigate the protein expression of extracellular signal-regulated kinase1/2 （ERK1/2） and phospho-extracellular signal-regulated kinase1/2 （p-ERK1/2） in hemangiomas,and to explore their role in the development of hemangiomas. Methods The protein expressions of ERK1/2 and p-ERK1/2 in 23 proliferating phase hemangiomas and 19 involuting phase hemangiomas were detected using immunohistochemical method （SP）. Results There was no significant difference in the the protein expression of ERK1/2 between proliferating hemangioma and involuting hemangioma （Z=-O.305,P〉O.05）. The expression of p-ERK1/2 protein in proliferating hemangioma was significantly higher than that in involuting hemangioma （Z=-4.271, P〈O.01）. Conclusions The overexpression of p- ERK1/2 and activation of ERK signalling pathway may be related with hemangiomatous proliferation.

关 键 词：血管瘤 细胞外信号调节激酶 磷酸化细胞外信号调节激酶 

分 类 号：R732.2[医药卫生—肿瘤]