Th17和FOXP3^+T在胃黏膜相关淋巴组织淋巴瘤发病中的意义  

Significance of Th17 and FOXP3^+ Regulatory T Cells in Pathogenesis of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

作　　者：陈广侠[1] 姜葵[1] 周璐[1] 徐东波[2] 王邦茂[1] 

机构地区：[1]天津医科大学总医院消化内科,天津市300052 [2]天津医科大学病理科

出　　处：《中国肿瘤临床》2012年第12期834-836,共3页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨Th17和FOXP3^+T(Treg)阳性细胞在慢性胃炎、淋巴细胞性胃炎和胃黏膜相关淋巴组织(MALT)淋巴瘤中的意义。方法:采用免疫组织化学方法检测18例慢性胃炎、17例淋巴细胞性胃炎和18例低度恶性胃MALT淋巴瘤组织中Th17及FOXP3^+T细胞的表达情况。结果:Th17在慢性胃炎组、淋巴细胞性胃炎组和胃MALT淋巴瘤组阳性细胞数分别为(11.2±2.4)、(15.1±5.3)和(16.8±5.4)个/每高倍镜视野,胃MALT淋巴瘤与慢性胃炎相比,差别有统计学意义(P<0.05),但胃MALT淋巴瘤与淋巴细胞性胃炎间差别无统计学意义(P>0.05)。FOXP3+T在慢性胃炎组、淋巴细胞性胃炎组和胃MALT淋巴瘤组的细胞数分别为(5.1±2.7)、(22.4+4.0)和(30.8±7.2)个/每高倍镜视野,三组间两两比较差异均有统计学意义(P<0.05)。FOXP3^+T和Th17细胞数量改变在胃MALT淋巴瘤组呈正相关(r=0.308,P<0.05)。结论:FOXP3^+T和Th17细胞数量在淋巴细胞性胃炎和胃MALF淋巴瘤组织中增多,可能在胃MALT淋巴瘤的发生、发展过程中发挥作用。Objective： To investigate the role of Thl7 and Treg in chronic gastritis, lymphocytic gastritis, and low-grade gastric mucosa-associated lymphoid tissue （ MALT ） lymphoma. Methods： The expression of FOXP3^＋Treg and Thl7 in 18 chronic gastritis, 17 lymphocytic gastritis, and 18 gastric MALT lymphoma cases were detected by immunohistochemical staining. Results： IL-17 ex- pression increased in the chronic gastritis, lymphocytic gastritis, and gastric MALT lymphoma cases. However, no statistical signifi- cance was found in IL-17 expression between lymphocytic gastritis and gastric MALT lymphoma. The expression of FOXP3^＋reg cells increased in the chronic gastritis, lymphocytic gastritis, and gastric MALT lymphoma cases （ P 〈 0.05 ） （ corresponding to 30.8 ± 7.2, 22.4 ± 4.0, and 5.1 ± 2.7 per high magnification field, respectively ）. The density of FOXP3^＋Treg cells was positively correlated with the expression of IL-17 （ r = 0.308, P 〈 0.05 ）. Conclusion： Thl 7 and Treg may play certain roles in the development of gastric MALT lymphoma.

关 键 词：TH17细胞 FOXP3^+调节T细胞 胃黏膜相关淋巴组织淋巴瘤 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]