磁共振全身成像在初诊鼻咽癌远处转移中的应用价值  

Whole-body Magnetic Resonance Imaging in Detecting Distant Metastases of Untreated Nasopharyngeal Carcinoma

作　　者：肖友平[1] 陈韵彬[1] 潘建基[2] 

机构地区：[1]福建省肿瘤医院放射诊断科,福州市350014 [2]福建省肿瘤医院放射治疗科

出　　处：《中国肿瘤临床》2012年第12期849-852,860,共5页Chinese Journal of Clinical Oncology

基　　金：福建省医学创新课题资助项目(编号:2009-CXB-29);福建省科技计划重点项目基金项目(编号:2060302)资助~~

摘　　要：目的:探讨磁共振全身成像对鼻咽癌初诊患者远处转移的诊断价值。方法:2008年11月至2009年8月对福建省肿瘤医院经病理证实的291例鼻咽癌初诊患者在治疗前一周内行全身磁共振成像(Whole Body Magnetic Resonance Imaging,WB-MRI)、X线胸片、肝脏超声和^(99m)Tc-MDP核素骨扫描,记录每例患者检出的骨、肺、肝转移灶数目,采用SPSS15.0统计软件,对几种影像方法各自检出的骨、肺、肝转移灶数目行McNemar's检验,比较检出率的差异。结果:本组研究共检出骨转移者24例,共发现骨转移灶95个,其中WB-MRI和骨扫描分别检出71个和36个,两者之间差异有统计学意义(P=0.004)。WB-MRI诊断出肺转移6例,而X线胸片诊断出3例,两者间差异无统计学意义(P>0.25);WB-MRI诊断出肝转移6例,而肝脏超声诊断处4例,两者间差异亦无统计学意义(P>0.05)。此外,WB-MRI和超声分别检出肝血管瘤12例和24例(P<0.01),以及肝囊肿34例和16例(P<0.005)。结论:WB-MRI在检测鼻咽癌全身远处转移有较高的应用价值,可作为其M分期的首选影像学检查。Objective： To evaluate the clinical value of whole body magnetic resonance imaging （ WB - MRI ） in detecting distant metastases of initial nasopharyngeal carcinoma （ NPC ）. Methods： Examinations of WB-MRI, bone scan, chest X-ray, and liver ultrasound were conducted on 291 consecutive NPC patients within one week before relative treatments. Two experienced radiologists interpreted the WB-MRI. Additional conventional MR or CT was performed on areas with abnormal lesions. Feasibility of metastatic lesions was pathologically confirmed, and all patients were clinically followed up with imaging modalities for at least 12 months. The number of bone, lung, and hepatic metastases detected by WB-MRI were separately compared with those detected by bone scan, chest X-ray, and liver ultrasound. All results were recorded and statistically analyzed by McNemar＇s test on SPSS （ Version 15.0 ）. Results： A total of 24 positive patients with bone metastases and 95 lesions of bone metastases were diagnosed by both WB-MRI and bone scan. Among these, 71 lesions were detected through WB-MRI and 36 lesions through bone scan. The difference between the results was significant, with WB-MRI higher than bone scan （ P = 0.004 ）. Apart from those with bone metastases, six patients with lung metastases were diagnosed by WB-MRI and three patients by chest X-ray. No significant difference was observed （ P 〉 0.25 ）. WB-MRI also diagnosed six hepatic metastases patients, whereas liver ultrasound detected only four. Similarly, there was no significant difference between them （ P 〉 0.5 ）. Furthermore, 24 patients were diagnosed with hepatic hemangioma through liver ultrasound, and 12 patients were diagnosed by WB-MR1, showing a significant difference between them （ P 〈 0.01 ）. By contrast, 34 patients with hepatic cysts were diagnosed by WB-MRI, and 16 patients were detected by liver ultrasound, showing a significant difference between them （ P 〈 0.005 ）. Conclusion： WB-MRI is valuable in detecting di

关 键 词：全身磁共振 弥散加权成像 鼻咽癌 远处转移 

分 类 号：R739.63[医药卫生—肿瘤]