软骨母细胞瘤9例临床病理分析  

Chondroblastoma:a clinicopathologic analysis of nine cases

作　　者：唐雪峰[1] 李龙辉[2] 许建平[1] 叶明福[1] 

机构地区：[1]第三军医大学新桥医院病理科,重庆400037 [2]第三军医大学新桥医院放射科,重庆400037

出　　处：《诊断病理学杂志》2012年第3期168-171,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨软骨母细胞瘤的临床、影像学和病理形态学特征,明确诊断要点。方法收集9例有完整临床资料的软骨母细胞瘤病例,对其临床、影像学和病理资料作回顾性分析。结果 9例患者中男性5例,女性4例,发病年龄14～33岁,平均年龄19.7岁,>20岁者2例。最常见的发病部位是股骨,主要症状是轻度局部疼痛。影像学上9例均为囊状溶骨性改变,术前只有1例确诊。镜下9例均能观察到软骨母细胞瘤的3种组成成分:软骨母细胞、破骨细胞样巨细胞和软骨基质。9例中7例软骨母细胞S-100(+)。结论软骨母细胞瘤的诊断需结合年龄、部位、影像学特点,并重点把握住软骨母细胞瘤的3种镜下成分。Objective To investigate the clinical, radiologic and pathological features of chondroblastoma, and to identify diagnostic criteria. Methods Nine cases of chondroblastoma from our hospital during the past 8 years were retrospectively analyzed on clinical and pathological features. Results Nine patients ranged in age from 14 to 33 years and mean ages was 19. 7, with only 2 patients over 20 years old. The most common anatomic site was femur. The main symptom was less severe local pain. Radiologic examination revealed typically lytic and osteolytic lesions in all cases. Only 1 case was accuratrely diagnosed clinically before the operation. Histologic features of chondroblastoma included 3 components： chondroblastic ceils, muhinucleated giant cells and cartilage matrix. 7 cases showed S-100 expression. Conclusion The diagnosis of chondroblastoma must be combined with the clinical features, image changes and presents of the three morphological components.

关 键 词：软骨母细胞瘤 骨肿瘤 诊断 

分 类 号：R738.3[医药卫生—肿瘤]