ZIC1、cyclinD1和p16在脂肪肉瘤中的表达及临床意义  

Expression of ZIC1,cyclinD1 and p16 and their clinical significance in liposarcoma

作　　者：林玲[1] 范钦和[1] 张玉梅[2] 

机构地区：[1]南京医科大学第一附属医院病理科,南京210029 [2]南京医科大学附属南京脑科医院病理科,南京210029

出　　处：《诊断病理学杂志》2012年第3期206-209,212,共5页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨ZIC1、cyclinD1和p16蛋白在脂肪肉瘤(LPS)中的表达及临床意义。方法运用免疫组化MaxVision快捷法检测52例LPS、20例脂肪瘤、15例正常脂肪组织中ZIC1、cyclinD1和p16蛋白的表达。结果ZIC1、cyclinD1和p16在LPS中过表达率分别为76.9%(40∕52)、67.3%(35∕52)和80.8%(42/52),表达水平明显高于脂肪瘤和正常脂肪组织(P<0.01)。ZIC1和cyclinD1的表达与LPS浸润或转移有关(P<0.05),而与肿瘤的发生部位、不同分化程度、原发与复发无关(P>0.05)。p16过表达与各项临床病理参数无关(P>0.05)。LPS中ZIC1过表达与cyclinD1高表达呈正相关(P<0.05),与p16过表达无关(P>0.05)。结论 ZIC1、cyclinD1和p16蛋白在LPS中高表达,表明三者在LPS的发生、发展过程中具有重要作用。三者在LPS中过表达对脂肪肿瘤的鉴别诊断有一定的意义。Objective To study the expression of ZIC1, cyclinD1 and p16 and their clinical significance in liposarcoma （LPS）. Methods Immunohistochemical MaxVision method was used to detect the expression of ZIC1, cyclinD1 and p16 proteins in 52 cases of LPS, 20 lipoma and 15 normal fat tissue. Results The overexpression rates of ZIC1, cyclinD1 and p16 were 76.9% （40 / 52）, 67.3% （35 / 52） and 80. 8% （42/52）, respectively, which were much higher than that of hpoma and normal fat tissue （P 〈 0.01 ）. The overexpression of ZIC1 and cyclinD1 in LPS was obviously associated with invasion or metastasis （ P 〈 0. 05 ）, but not with tumor sites （ P 〉 0. 05 ）, differentiation degree （P 〉 0. 05 ） and primary or recurrence group （ P 〉 0. 05 ）. No relationship was found between p16 overexpression and clinicopathological features. Overexpression of ZIC1 was positively correlated with high expression of cyclinD1 in LPS （P 〈 0. 05）, but no statistical relation between overexpression of ZICI and p16 was observed （P 〉 0. 05）. Conclusion Overexpression of ZIC1, cyclinD1 and p16 in LPS may play an important role in the carcinogenesis and progression of LPS and may be helpful in the differential diagnosis.

关 键 词：脂肪肉瘤 ZIC1 CYCLIND1 P16 免疫组化 

分 类 号：R738.6[医药卫生—肿瘤]