甲状腺乳头状癌中PPM1D的表达和意义  

Expression of PPM1D in papillary carcinoma of thyroid and its significance

作　　者：任伟民[1] 张友元[1] 罗金芳[1] 叶宣光[1] 董军明[1] 

机构地区：[1]复旦大学附属金山医院病理科,上海200540

出　　处：《临床与实验病理学杂志》2012年第6期623-626,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：上海市卫生局面上项目(2010-51)

摘　　要：目的探讨甲状腺乳头状癌(papillary carcinoma of thyroid,PTC)中PPM1D蛋白的表达情况及其与临床病理特征和p53的关系。方法应用免疫组化EnVision法检测55例PTC及癌旁正常组织中PPM1D蛋白的表达情况并进行统计处理,分析其与临床病理特征的关系及和p53蛋白表达的相关性。结果 55例PTC中PPM1D的表达(74.5%,41/55)高于癌旁正常组织(10.9%,6/55),差异有统计学意义;PPPM1D的表达与患者年龄、性别、肿瘤大小、组织学类型、淋巴结转移、TNM分期无关,而在间质硬化的病例中表达增强(P<0.05);PTC中PPM1D与p53蛋白表达呈负相关(r=-0.339,P<0.05)。结论高表达的PPM1D与PTC相关,与p53之间可能存在相互作用,在PTC发生、发展中具有重要意义。Purpose To investigate the expression of PPM1D in papillary carcinoma of thyroid （PTC） and its relationship with clinico- pathologic features and p53. Methods The expression of PPM1 D protein was detected in 55 cases of PTC tissues compared with nor- mal tumor-adjacent thyroid tissues by immunohistochemistry. The data was analyzed statistically to evaluate the relationship between the expression of PPM1 D, p53 and the clinicopathologic features. Results The expression of PPM1D was much higher in PTC （74. 5% , 41/55） than that in normal tumor-adjacent thyroid tissues（ 10. 9%, 6/55 ）. The difference was statistically significant（ P 〈 0. 05 ）. PPM1D was found high-expressed in PTC with interstitial cirrhosis （P 〈 0. 05 ）. PPM1D also showed negative correlation with p53 （r = - 0. 339, P 〈 0. 05 ） in PTC. Conclusions Increased expression of PPM1D is associated with thyroid papillary carcinoma and the po- tential coordination between PPM1D and p53 may play an important role in the process of tumor genesis and development.

关 键 词：甲状腺肿瘤 乳头状癌 PPM1D P53 免疫组织化学 

分 类 号：R736.1[医药卫生—肿瘤]